Adaptive Estimation of Personalized Maximum Tolerated Dose in Cancer Phase I Clinical Trials Based on All Toxicities and Individual Genomic Profile

• Zhengjia Chen ,

  * E-mail: zchen38@emory.edu

  Affiliations Department of Biostatistics and Bioinformatics, Emory University, Atlanta, Georgia, United States of America, Biostatistics and Bioinformatics Shared Resource, Winship Cancer Institute, Emory University, Atlanta, Georgia, United States of America

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• Zheng Li,

  Affiliation Division of Biostatistics and Bioinformatics, Pennsylvania State University, Hershey, Pennsylvania, United States of America

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• Run Zhuang,

  Affiliation Department of Biostatistics and Bioinformatics, Emory University, Atlanta, Georgia, United States of America

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• Ying Yuan,

  Affiliation Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America

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• Michael Kutner,

  Affiliation Department of Biostatistics and Bioinformatics, Emory University, Atlanta, Georgia, United States of America

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• Taofeek Owonikoko,

  Affiliation Department of Hematology and Medical Oncology, Emory University, Atlanta, Georgia, United States of America

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• Walter J. Curran,

  Affiliation Department of Radiation Oncology, Emory University, Atlanta, Georgia, United States of America

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• Jeanne Kowalski

  Affiliations Department of Biostatistics and Bioinformatics, Emory University, Atlanta, Georgia, United States of America, Biostatistics and Bioinformatics Shared Resource, Winship Cancer Institute, Emory University, Atlanta, Georgia, United States of America

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