Upon Accounting for the Impact of Isoenzyme Loss, Gene Deletion Costs Anticorrelate with Their Evolutionary Rates

Open Access

Peer-reviewed

Research Article

Christopher Jacobs ,

Contributed equally to this work with: Christopher Jacobs, Luke Lambourne

Affiliation Bioinformatics Program, Boston University, Boston, Massachusetts, United States of America

http://orcid.org/0000-0002-6034-1873

⨯
Luke Lambourne ,

Contributed equally to this work with: Christopher Jacobs, Luke Lambourne

Affiliations Bioinformatics Program, Boston University, Boston, Massachusetts, United States of America, Department of Bioengineering, Faculty of Engineering, McGill University, Montreal, Quebec, Canada
⨯
Yu Xia,

Affiliations Bioinformatics Program, Boston University, Boston, Massachusetts, United States of America, Department of Bioengineering, Faculty of Engineering, McGill University, Montreal, Quebec, Canada
⨯
Daniel Segrè

* E-mail: dsegre@bu.edu

Affiliations Bioinformatics Program, Boston University, Boston, Massachusetts, United States of America, Department of Biology, Boston University, Boston, Massachusetts, United States of America, Department of Biomedical Engineering, Boston University, Boston, Massachusetts, United States of America
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Evolutionary rate
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Deletion mutation
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Saccharomyces cerevisiae
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Enzyme metabolism
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Enzymes
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Gene mapping
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Evolutionary genetics
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Fitness epistasis
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