Expression Profiling of Ribosome Biogenesis Factors Reveals Nucleolin as a Novel Potential Marker to Predict Outcome in AML Patients

Virginie Marcel; Frédéric Catez; Caroline M. Berger; Emeline Perrial; Adriana Plesa; Xavier Thomas; Eve Mattei; Sandrine Hayette; Pierre Saintigny; Philippe Bouvet; Jean-Jacques Diaz; Charles Dumontet

doi:10.1371/journal.pone.0170160

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Open Access

Peer-reviewed

Research Article

Expression Profiling of Ribosome Biogenesis Factors Reveals Nucleolin as a Novel Potential Marker to Predict Outcome in AML Patients

Virginie Marcel ,

Contributed equally to this work with: Virginie Marcel, Frédéric Catez

Affiliations Cancer Research Center of Lyon, UMR INSERM 1052 CNRS 5286, Centre Léon Bérard, Lyon, France, Université Lyon 1, Lyon, France, Nuclear domains and pathologies team, Cancer Cell Plasticity Department, Lyon, France
⨯
Frédéric Catez ,

Contributed equally to this work with: Virginie Marcel, Frédéric Catez

Affiliations Cancer Research Center of Lyon, UMR INSERM 1052 CNRS 5286, Centre Léon Bérard, Lyon, France, Université Lyon 1, Lyon, France, Nuclear domains and pathologies team, Cancer Cell Plasticity Department, Lyon, France
⨯
Caroline M. Berger,

Affiliations Cancer Research Center of Lyon, UMR INSERM 1052 CNRS 5286, Centre Léon Bérard, Lyon, France, Université Lyon 1, Lyon, France, Nuclear domains and pathologies team, Cancer Cell Plasticity Department, Lyon, France
⨯
Emeline Perrial,

Affiliations Cancer Research Center of Lyon, UMR INSERM 1052 CNRS 5286, Centre Léon Bérard, Lyon, France, Université Lyon 1, Lyon, France, Anticancer antibodies team, Immunity, Microenvironment and Virus Department, Lyon, France
⨯
Adriana Plesa,

Affiliation Department of Biology, Hospices Civils de Lyon, Centre Hospitalier Lyon Sud, Pierre Bénite, France
⨯
Xavier Thomas,

Affiliation Department of Hematology, Hospices Civils de Lyon, Centre Hospitalier Lyon Sud, Pierre Bénite, France
⨯
Eve Mattei,

Affiliation Department of Biology, Hospices Civils de Lyon, Centre Hospitalier Lyon Sud, Pierre Bénite, France
⨯
Sandrine Hayette,

Affiliation Department of Biology, Hospices Civils de Lyon, Centre Hospitalier Lyon Sud, Pierre Bénite, France
⨯
Pierre Saintigny,

Affiliations Cancer Research Center of Lyon, UMR INSERM 1052 CNRS 5286, Centre Léon Bérard, Lyon, France, Université Lyon 1, Lyon, France, Department of Medecine, Centre Léon Bérard, Lyon, France
⨯
Philippe Bouvet,

Affiliations Cancer Research Center of Lyon, UMR INSERM 1052 CNRS 5286, Centre Léon Bérard, Lyon, France, Université Lyon 1, Lyon, France, Nuclear domains and pathologies team, Cancer Cell Plasticity Department, Lyon, France, Ecole Normale Supérieure de Lyon, Lyon, France
⨯
Jean-Jacques Diaz ,

* E-mail: charles.dumontet@chu-lyon.fr (CD); jean-jacques.diaz@lyon.unicancer.fr (JJD)

¶‡ These authors contributed equally to this work as senior authors.

Affiliations Cancer Research Center of Lyon, UMR INSERM 1052 CNRS 5286, Centre Léon Bérard, Lyon, France, Université Lyon 1, Lyon, France, Nuclear domains and pathologies team, Cancer Cell Plasticity Department, Lyon, France
⨯
Charles Dumontet

* E-mail: charles.dumontet@chu-lyon.fr (CD); jean-jacques.diaz@lyon.unicancer.fr (JJD)

¶‡ These authors contributed equally to this work as senior authors.

Affiliations Cancer Research Center of Lyon, UMR INSERM 1052 CNRS 5286, Centre Léon Bérard, Lyon, France, Université Lyon 1, Lyon, France, Anticancer antibodies team, Immunity, Microenvironment and Virus Department, Lyon, France
⨯

Expression Profiling of Ribosome Biogenesis Factors Reveals Nucleolin as a Novel Potential Marker to Predict Outcome in AML Patients

Virginie Marcel,
Frédéric Catez,
Caroline M. Berger,
Emeline Perrial,
Adriana Plesa,
Xavier Thomas,
Eve Mattei,
Sandrine Hayette,
Pierre Saintigny,
Philippe Bouvet

Published: January 19, 2017
https://doi.org/10.1371/journal.pone.0170160

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Acute myeloid leukemia
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Ribosomes
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Biosynthesis
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Gene expression
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Bone marrow cells
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