Resistance for Genotoxic Damage in Mesenchymal Stromal Cells Is Increased by Hypoxia but Not Generally Dependent on p53-Regulated Cell Cycle Arrest

Jana Lützkendorf; Elisabeth Wieduwild; Katrin Nerger; Nina Lambrecht; Hans-Joachim Schmoll; Carsten Müller-Tidow; Lutz Peter Müller

doi:10.1371/journal.pone.0169921

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Peer-reviewed

Research Article

Resistance for Genotoxic Damage in Mesenchymal Stromal Cells Is Increased by Hypoxia but Not Generally Dependent on p53-Regulated Cell Cycle Arrest

Jana Lützkendorf ,

* E-mail: jana.luetzkendorf@medizin.uni-halle.de

Affiliation Universitätsklinik und Poliklinik für Innere Medizin IV, Hämatologie/Onkologie, Martin-Luther-Universität Halle-Wittenberg, Halle (Saale), Germany

http://orcid.org/0000-0002-5781-9266

⨯
Elisabeth Wieduwild,

Current address: Centre d'Immunologie de Marseille-Luminy, Université Aix-Marseille, Inserm, Centre national de la recherche scientifique, Marseille, France

Affiliation Universitätsklinik und Poliklinik für Innere Medizin IV, Hämatologie/Onkologie, Martin-Luther-Universität Halle-Wittenberg, Halle (Saale), Germany
⨯
Katrin Nerger,

Affiliation Universitätsklinik und Poliklinik für Innere Medizin IV, Hämatologie/Onkologie, Martin-Luther-Universität Halle-Wittenberg, Halle (Saale), Germany
⨯
Nina Lambrecht,

Current address: Universitätsklinik und Poliklinik für Innere Medizin I, Gastroenterologie/Pneumologie, Martin-Luther-Universität Halle-Wittenberg, Halle (Saale), Germany

Affiliation Universitätsklinik und Poliklinik für Innere Medizin IV, Hämatologie/Onkologie, Martin-Luther-Universität Halle-Wittenberg, Halle (Saale), Germany
⨯
Hans-Joachim Schmoll,

Affiliation Universitätsklinik und Poliklinik für Innere Medizin IV, Hämatologie/Onkologie, Martin-Luther-Universität Halle-Wittenberg, Halle (Saale), Germany
⨯
Carsten Müller-Tidow,

Affiliation Universitätsklinik und Poliklinik für Innere Medizin IV, Hämatologie/Onkologie, Martin-Luther-Universität Halle-Wittenberg, Halle (Saale), Germany
⨯
Lutz Peter Müller

Affiliation Universitätsklinik und Poliklinik für Innere Medizin IV, Hämatologie/Onkologie, Martin-Luther-Universität Halle-Wittenberg, Halle (Saale), Germany
⨯

Resistance for Genotoxic Damage in Mesenchymal Stromal Cells Is Increased by Hypoxia but Not Generally Dependent on p53-Regulated Cell Cycle Arrest

Jana Lützkendorf,
Elisabeth Wieduwild,
Katrin Nerger,
Nina Lambrecht,
Hans-Joachim Schmoll,
Carsten Müller-Tidow,
Lutz Peter Müller

Published: January 12, 2017
https://doi.org/10.1371/journal.pone.0169921

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Mesenchymal stem cells
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Cell cycle and cell division
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Hypoxia
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Oxygen
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Cloning
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Apoptosis
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Cell differentiation
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Cell staining
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