Dietary Chromium Restriction of Pregnant Mice Changes the Methylation Status of Hepatic Genes Involved with Insulin Signaling in Adult Male Offspring

Qian Zhang; Xiaofang Sun; Xinhua Xiao; Jia Zheng; Ming Li; Miao Yu; Fan Ping; Zhixin Wang; Cuijuan Qi; Tong Wang; Xiaojing Wang

doi:10.1371/journal.pone.0169889

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Open Access

Peer-reviewed

Research Article

Dietary Chromium Restriction of Pregnant Mice Changes the Methylation Status of Hepatic Genes Involved with Insulin Signaling in Adult Male Offspring

Qian Zhang,

Affiliation Key Laboratory of Endocrinology, Translational Medicine Centre, Ministry of Health, Department of Endocrinology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China
⨯
Xiaofang Sun,

Affiliation Department of Endocrinology, the Affiliated Hospital of Qingdao University, Qingdao, Shandong, China
⨯
Xinhua Xiao ,

* E-mail: xiaoxh2014@vip.163.com

Affiliation Key Laboratory of Endocrinology, Translational Medicine Centre, Ministry of Health, Department of Endocrinology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China
⨯
Jia Zheng,

Affiliation Key Laboratory of Endocrinology, Translational Medicine Centre, Ministry of Health, Department of Endocrinology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China
⨯
Ming Li,

Affiliation Key Laboratory of Endocrinology, Translational Medicine Centre, Ministry of Health, Department of Endocrinology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China
⨯
Miao Yu,

Affiliation Key Laboratory of Endocrinology, Translational Medicine Centre, Ministry of Health, Department of Endocrinology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China
⨯
Fan Ping,

Affiliation Key Laboratory of Endocrinology, Translational Medicine Centre, Ministry of Health, Department of Endocrinology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China
⨯
Zhixin Wang,

Affiliation Key Laboratory of Endocrinology, Translational Medicine Centre, Ministry of Health, Department of Endocrinology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China
⨯
Cuijuan Qi,

Affiliation Key Laboratory of Endocrinology, Translational Medicine Centre, Ministry of Health, Department of Endocrinology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China
⨯
Tong Wang,

Affiliation Key Laboratory of Endocrinology, Translational Medicine Centre, Ministry of Health, Department of Endocrinology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China
⨯
Xiaojing Wang

Affiliation Key Laboratory of Endocrinology, Translational Medicine Centre, Ministry of Health, Department of Endocrinology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China
⨯

Dietary Chromium Restriction of Pregnant Mice Changes the Methylation Status of Hepatic Genes Involved with Insulin Signaling in Adult Male Offspring

Qian Zhang,
Xiaofang Sun,
Xinhua Xiao,
Jia Zheng,
Ming Li,
Miao Yu,
Fan Ping,
Zhixin Wang,
Cuijuan Qi,
Tong Wang

Published: January 10, 2017
https://doi.org/10.1371/journal.pone.0169889

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