The AMPK Activator A769662 Blocks Voltage-Gated Sodium Channels: Discovery of a Novel Pharmacophore with Potential Utility for Analgesic Development

Marina N. Asiedu; Chongyang Han; Sulayman D. Dib-Hajj; Stephen G. Waxman; Theodore J. Price; Gregory Dussor

doi:10.1371/journal.pone.0169882

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Research Article

The AMPK Activator A769662 Blocks Voltage-Gated Sodium Channels: Discovery of a Novel Pharmacophore with Potential Utility for Analgesic Development

Marina N. Asiedu,

Affiliations University of Arizona, Department of Pharmacology, Tucson, Arizona, United States of America, University of Texas at Dallas, School of Behavioral and Brain Sciences, Richardson, Texas, United States of America
⨯
Chongyang Han,

Affiliation Yale School of Medicine, Department of Neurology, Center for Neuroscience and Regeneration Research, and Veterans Administration Connecticut Healthcare System, Rehabilitation Research Center, West Haven, Connecticut, United States of America
⨯
Sulayman D. Dib-Hajj,

Affiliation Yale School of Medicine, Department of Neurology, Center for Neuroscience and Regeneration Research, and Veterans Administration Connecticut Healthcare System, Rehabilitation Research Center, West Haven, Connecticut, United States of America
⨯
Stephen G. Waxman,

Affiliation Yale School of Medicine, Department of Neurology, Center for Neuroscience and Regeneration Research, and Veterans Administration Connecticut Healthcare System, Rehabilitation Research Center, West Haven, Connecticut, United States of America
⨯
Theodore J. Price,

Affiliations University of Arizona, Department of Pharmacology, Tucson, Arizona, United States of America, University of Texas at Dallas, School of Behavioral and Brain Sciences, Richardson, Texas, United States of America
⨯
Gregory Dussor

* E-mail: gregory.dussor1@utdallas.edu

Affiliations University of Arizona, Department of Pharmacology, Tucson, Arizona, United States of America, University of Texas at Dallas, School of Behavioral and Brain Sciences, Richardson, Texas, United States of America
⨯

The AMPK Activator A769662 Blocks Voltage-Gated Sodium Channels: Discovery of a Novel Pharmacophore with Potential Utility for Analgesic Development

Marina N. Asiedu,
Chongyang Han,
Sulayman D. Dib-Hajj,
Stephen G. Waxman,
Theodore J. Price,
Gregory Dussor

Published: January 24, 2017
https://doi.org/10.1371/journal.pone.0169882

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