Narcolepsy Type 1 Is Associated with a Systemic Increase and Activation of Regulatory T Cells and with a Systemic Activation of Global T Cells

Michel Lecendreux; Guillaume Churlaud; Fabien Pitoiset; Armelle Regnault; Tu Anh Tran; Roland Liblau; David Klatzmann; Michelle Rosenzwajg

doi:10.1371/journal.pone.0169836

Loading metrics

Open Access

Peer-reviewed

Research Article

Narcolepsy Type 1 Is Associated with a Systemic Increase and Activation of Regulatory T Cells and with a Systemic Activation of Global T Cells

Michel Lecendreux ,

Contributed equally to this work with: Michel Lecendreux, Guillaume Churlaud

Affiliations AP-HP, Pediatric Sleep Center and National Reference Centre for Orphan Diseases, Narcolepsy, Idiopathic Hypersomnia and Kleine-Levin Syndrome (CNR narcolepsie-hypersomnie), CHU Robert-Debré, Paris, France, Pediatric Sleep Disorders Center, Robert Debré Hospital, Paris, France
⨯
Guillaume Churlaud ,

Contributed equally to this work with: Michel Lecendreux, Guillaume Churlaud

Affiliations AP-HP, Hôpital Pitié-Salpêtrière, Biotherapy (CIC-BTi) and Inflammation-Immunopathology-Biotherapy Department (I2B), Paris, France, Sorbonne Université, UPMC Univ Paris 06, UMRS 959, Immunology-Immunopathology- Immunotherapy (I3), Paris, France, INSERM, UMR_S 959, Immunology-Immunopathology-Immunotherapy (I3), Paris, France
⨯
Fabien Pitoiset,

Affiliations AP-HP, Hôpital Pitié-Salpêtrière, Biotherapy (CIC-BTi) and Inflammation-Immunopathology-Biotherapy Department (I2B), Paris, France, Sorbonne Université, UPMC Univ Paris 06, UMRS 959, Immunology-Immunopathology- Immunotherapy (I3), Paris, France, INSERM, UMR_S 959, Immunology-Immunopathology-Immunotherapy (I3), Paris, France
⨯
Armelle Regnault,

Affiliation Aviesan/Institut Multi-Organismes Immunologie, Hématologie et Pneumologie (ITMO IHP), Paris, France
⨯
Tu Anh Tran,

Affiliation Pediatrics department, Centre hospitalo-universitaire de Nîmes, 30029 Nîmes Cedex 9, France. INSERM U1012, Le Kremlin Bicêtre, France
⨯
Roland Liblau,

Affiliation INSERM UMR1043—CNRS UMR5282—Université Toulouse III, Toulouse, France
⨯
David Klatzmann,

Affiliations AP-HP, Hôpital Pitié-Salpêtrière, Biotherapy (CIC-BTi) and Inflammation-Immunopathology-Biotherapy Department (I2B), Paris, France, Sorbonne Université, UPMC Univ Paris 06, UMRS 959, Immunology-Immunopathology- Immunotherapy (I3), Paris, France, INSERM, UMR_S 959, Immunology-Immunopathology-Immunotherapy (I3), Paris, France
⨯
Michelle Rosenzwajg

* E-mail: michelle.rosenzwajg@upmc.fr

Affiliations AP-HP, Hôpital Pitié-Salpêtrière, Biotherapy (CIC-BTi) and Inflammation-Immunopathology-Biotherapy Department (I2B), Paris, France, Sorbonne Université, UPMC Univ Paris 06, UMRS 959, Immunology-Immunopathology- Immunotherapy (I3), Paris, France, INSERM, UMR_S 959, Immunology-Immunopathology-Immunotherapy (I3), Paris, France
⨯

Narcolepsy Type 1 Is Associated with a Systemic Increase and Activation of Regulatory T Cells and with a Systemic Activation of Global T Cells

Michel Lecendreux,
Guillaume Churlaud,
Fabien Pitoiset,
Armelle Regnault,
Tu Anh Tran,
Roland Liblau,
David Klatzmann,
Michelle Rosenzwajg

Published: January 20, 2017
https://doi.org/10.1371/journal.pone.0169836

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Regulatory T cells
Is the Subject Area "Regulatory T cells" applicable to this article?

Thanks for your feedback.
T cells
Is the Subject Area "T cells" applicable to this article?

Thanks for your feedback.
H1N1
Is the Subject Area "H1N1" applicable to this article?

Thanks for your feedback.
Cytotoxic T cells
Is the Subject Area "Cytotoxic T cells" applicable to this article?

Thanks for your feedback.
Cytokines
Is the Subject Area "Cytokines" applicable to this article?

Thanks for your feedback.
Narcolepsy
Is the Subject Area "Narcolepsy" applicable to this article?

Thanks for your feedback.
Vaccination and immunization
Is the Subject Area "Vaccination and immunization" applicable to this article?

Thanks for your feedback.
B cells
Is the Subject Area "B cells" applicable to this article?

Thanks for your feedback.