Leukotriene B₄ Metabolism and p70S6 Kinase 1 Inhibitors: PF-4708671 but Not LY2584702 Inhibits CYP4F3A and the ω-Oxidation of Leukotriene B₄ In Vitro and In Cellulo

Anne-Sophie Archambault; Caroline Turcotte; Cyril Martin; Julie S. Lefebvre; Véronique Provost; Michel Laviolette; Nicolas Flamand

doi:10.1371/journal.pone.0169804

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Research Article

Leukotriene B₄ Metabolism and p70S6 Kinase 1 Inhibitors: PF-4708671 but Not LY2584702 Inhibits CYP4F3A and the ω-Oxidation of Leukotriene B₄ In Vitro and In Cellulo

Anne-Sophie Archambault,

Affiliations Centre de recherche de l’Institut universitaire de cardiologie et de pneumologie de Québec, Québec City, Québec, Canada, Département de médecine, Faculté de médecine, Université Laval, Québec City, Québec, Canada
⨯
Caroline Turcotte,

Affiliations Centre de recherche de l’Institut universitaire de cardiologie et de pneumologie de Québec, Québec City, Québec, Canada, Département de médecine, Faculté de médecine, Université Laval, Québec City, Québec, Canada
⨯
Cyril Martin,

Affiliation Centre de recherche de l’Institut universitaire de cardiologie et de pneumologie de Québec, Québec City, Québec, Canada
⨯
Julie S. Lefebvre,

Affiliation Centre de recherche de l’Institut universitaire de cardiologie et de pneumologie de Québec, Québec City, Québec, Canada
⨯
Véronique Provost,

Affiliation Centre de recherche de l’Institut universitaire de cardiologie et de pneumologie de Québec, Québec City, Québec, Canada
⨯
Michel Laviolette,

Affiliations Centre de recherche de l’Institut universitaire de cardiologie et de pneumologie de Québec, Québec City, Québec, Canada, Département de médecine, Faculté de médecine, Université Laval, Québec City, Québec, Canada
⨯
Nicolas Flamand

* E-mail: Nicolas.Flamand@criucpq.ulaval.ca

Affiliations Centre de recherche de l’Institut universitaire de cardiologie et de pneumologie de Québec, Québec City, Québec, Canada, Département de médecine, Faculté de médecine, Université Laval, Québec City, Québec, Canada

http://orcid.org/0000-0001-5944-7200

⨯

Leukotriene B₄ Metabolism and p70S6 Kinase 1 Inhibitors: PF-4708671 but Not LY2584702 Inhibits CYP4F3A and the ω-Oxidation of Leukotriene B₄ In Vitro and In Cellulo

Anne-Sophie Archambault,
Caroline Turcotte,
Cyril Martin,
Julie S. Lefebvre,
Véronique Provost,
Michel Laviolette,
Nicolas Flamand

Published: January 9, 2017
https://doi.org/10.1371/journal.pone.0169804

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