Sequential Targeting of CD52 and TNF Allows Early Minimization Therapy in Kidney Transplantation: From a Biomarker to Targeting in a Proof-Of-Concept Trial

Ondrej Viklicky; Petra Hruba; Stefan Tomiuk; Sabrina Schmitz; Bernhard Gerstmayer; Birgit Sawitzki; Patrick Miqueu; Petra Mrazova; Irena Tycova; Eva Svobodova; Eva Honsova; Uwe Janssen; Hans-Dieter Volk; Petra Reinke

doi:10.1371/journal.pone.0169624

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Open Access

Peer-reviewed

Research Article

Sequential Targeting of CD52 and TNF Allows Early Minimization Therapy in Kidney Transplantation: From a Biomarker to Targeting in a Proof-Of-Concept Trial

Ondrej Viklicky ,

* E-mail: ondrej.viklicky@ikem.cz

Affiliations Department of Nephrology, Institute for Clinical and Experimental Medicine, Prague, Czech Republic, Transplant Laboratory, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
⨯
Petra Hruba,

Affiliation Transplant Laboratory, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
⨯
Stefan Tomiuk,

Affiliation Miltenyi Biotec GmbH, Bergisch Gladbach, Germany
⨯
Sabrina Schmitz,

Affiliation Miltenyi Biotec GmbH, Bergisch Gladbach, Germany
⨯
Bernhard Gerstmayer,

Affiliation Miltenyi Biotec GmbH, Bergisch Gladbach, Germany
⨯
Birgit Sawitzki,

Affiliations Institute of Medical Immunology, Charité University Medicine Berlin, Germany, Berlin-Brandenburg Center for Regenerative Medicine (BCRT), Charité University Medicine Berlin, Germany
⨯
Patrick Miqueu,

Affiliations Institut National de la Santé et de la Recherche Médicale INSERM U1064, France, Institut de Transplantation Urologie Néphrologie du Centre Hospitalier Universitaire Hôtel Dieu, Nantes, France
⨯
Petra Mrazova,

Affiliation Transplant Laboratory, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
⨯
Irena Tycova,

Affiliation Transplant Laboratory, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
⨯
Eva Svobodova,

Affiliation Department of Immunogenetics, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
⨯
Eva Honsova,

Affiliation Department of Clinical and Transplant Pathology, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
⨯
Uwe Janssen,

Affiliation Miltenyi Biotec GmbH, Bergisch Gladbach, Germany
⨯
Hans-Dieter Volk ,

Contributed equally to this work with: Hans-Dieter Volk, Petra Reinke

¶‡ These authors are joint senior authors on this work.

Affiliations Institute of Medical Immunology, Charité University Medicine Berlin, Germany, Berlin-Brandenburg Center for Regenerative Medicine (BCRT), Charité University Medicine Berlin, Germany
⨯
Petra Reinke

Contributed equally to this work with: Hans-Dieter Volk, Petra Reinke

¶‡ These authors are joint senior authors on this work.

Affiliations Berlin-Brandenburg Center for Regenerative Medicine (BCRT), Charité University Medicine Berlin, Germany, Department of Nephrology and Intensive Care Medicine, Charité University Medicine Berlin, Germany
⨯

Sequential Targeting of CD52 and TNF Allows Early Minimization Therapy in Kidney Transplantation: From a Biomarker to Targeting in a Proof-Of-Concept Trial

Ondrej Viklicky,
Petra Hruba,
Stefan Tomiuk,
Sabrina Schmitz,
Bernhard Gerstmayer,
Birgit Sawitzki,
Patrick Miqueu,
Petra Mrazova,
Irena Tycova,
Eva Svobodova

Published: January 13, 2017
https://doi.org/10.1371/journal.pone.0169624

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