Time-Dependent Structural Alteration of Rituximab Analyzed by LC/TOF-MS after a Systemic Administration to Rats

Yuki Otani; Atushi Yonezawa; Masahiro Tsuda; Satoshi Imai; Yasuaki Ikemi; Shunsaku Nakagawa; Tomohiro Omura; Takayuki Nakagawa; Ikuko Yano; Kazuo Matsubara

doi:10.1371/journal.pone.0169588

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Open Access

Peer-reviewed

Research Article

Time-Dependent Structural Alteration of Rituximab Analyzed by LC/TOF-MS after a Systemic Administration to Rats

Yuki Otani,

Affiliation Department of Clinical Pharmacology and Therapeutics, Kyoto University Hospital, Kyoto, Japan
⨯
Atushi Yonezawa ,

* E-mail: ayone@kuhp.kyoto-u.ac.jp

Affiliations Department of Clinical Pharmacology and Therapeutics, Kyoto University Hospital, Kyoto, Japan, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan

http://orcid.org/0000-0002-8057-6768

⨯
Masahiro Tsuda,

Affiliations Department of Clinical Pharmacology and Therapeutics, Kyoto University Hospital, Kyoto, Japan, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan
⨯
Satoshi Imai,

Affiliation Department of Clinical Pharmacology and Therapeutics, Kyoto University Hospital, Kyoto, Japan
⨯
Yasuaki Ikemi,

Affiliation Department of Clinical Pharmacology and Therapeutics, Kyoto University Hospital, Kyoto, Japan
⨯
Shunsaku Nakagawa,

Affiliation Department of Clinical Pharmacology and Therapeutics, Kyoto University Hospital, Kyoto, Japan
⨯
Tomohiro Omura,

Affiliation Department of Clinical Pharmacology and Therapeutics, Kyoto University Hospital, Kyoto, Japan
⨯
Takayuki Nakagawa,

Affiliation Department of Clinical Pharmacology and Therapeutics, Kyoto University Hospital, Kyoto, Japan
⨯
Ikuko Yano,

Current address: Department of Pharmacy, Kobe University Hospital, Kobe, Japan

Affiliations Department of Clinical Pharmacology and Therapeutics, Kyoto University Hospital, Kyoto, Japan, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan
⨯
Kazuo Matsubara

Affiliation Department of Clinical Pharmacology and Therapeutics, Kyoto University Hospital, Kyoto, Japan
⨯

Time-Dependent Structural Alteration of Rituximab Analyzed by LC/TOF-MS after a Systemic Administration to Rats

Yuki Otani,
Atushi Yonezawa,
Masahiro Tsuda,
Satoshi Imai,
Yasuaki Ikemi,
Shunsaku Nakagawa,
Tomohiro Omura,
Takayuki Nakagawa,
Ikuko Yano,
Kazuo Matsubara

Published: January 4, 2017
https://doi.org/10.1371/journal.pone.0169588

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