Genome-Wide DNA Methylation Analysis of Chinese Patients with Systemic Lupus Erythematosus Identified Hypomethylation in Genes Related to the Type I Interferon Pathway

Kit San Yeung; Brian Hon-Yin Chung; Sanaa Choufani; Mo Yin Mok; Wai Lap Wong; Christopher Chun Yu Mak; Wanling Yang; Pamela Pui Wah Lee; Wilfred Hing Sang Wong; Yi-an Chen; Daria Grafodatskaya; Raymond Woon Sing Wong; Chak Sing Lau; Daniel Tak Mao Chan; Rosanna Weksberg; Yu-Lung Lau

doi:10.1371/journal.pone.0169553

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Peer-reviewed

Research Article

Genome-Wide DNA Methylation Analysis of Chinese Patients with Systemic Lupus Erythematosus Identified Hypomethylation in Genes Related to the Type I Interferon Pathway

Kit San Yeung,

Affiliation Department of Paediatrics and Adolescent Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China
⨯
Brian Hon-Yin Chung ,

* E-mail: bhychung@hku.hk

Affiliation Department of Paediatrics and Adolescent Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China
⨯
Sanaa Choufani,

Affiliation Genetics and Genome Biology Program, The Hospital for Sick Children Research Institute, Toronto, Canada
⨯
Mo Yin Mok,

Affiliations Department of Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China, Department of Biomedical Sciences, The City University of Hong Kong, Hong Kong, China
⨯
Wai Lap Wong,

Affiliation Department of Paediatrics and Adolescent Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China
⨯
Christopher Chun Yu Mak,

Affiliation Department of Paediatrics and Adolescent Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China
⨯
Wanling Yang,

Affiliation Department of Paediatrics and Adolescent Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China
⨯
Pamela Pui Wah Lee,

Affiliation Department of Paediatrics and Adolescent Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China
⨯
Wilfred Hing Sang Wong,

Affiliation Department of Paediatrics and Adolescent Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China
⨯
Yi-an Chen,

Affiliation Genetics and Genome Biology Program, The Hospital for Sick Children Research Institute, Toronto, Canada
⨯
Daria Grafodatskaya,

Affiliation Genetics and Genome Biology Program, The Hospital for Sick Children Research Institute, Toronto, Canada
⨯
Raymond Woon Sing Wong,

Affiliation Department of Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China
⨯
Chak Sing Lau,

Affiliation Department of Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China
⨯
Daniel Tak Mao Chan,

Affiliation Department of Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China
⨯
Rosanna Weksberg,

Affiliations Genetics and Genome Biology Program, The Hospital for Sick Children Research Institute, Toronto, Canada, Division of Clinical and Metabolic Genetics, The Hospital for Sick Children, Toronto, Ontario, Canada, Institute of Medical Science and Department of Pediatrics, University of Toronto, Toronto, Ontario, Canada
⨯
[ ... ],
Yu-Lung Lau

Affiliation Department of Paediatrics and Adolescent Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China
⨯
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Genome-Wide DNA Methylation Analysis of Chinese Patients with Systemic Lupus Erythematosus Identified Hypomethylation in Genes Related to the Type I Interferon Pathway

Kit San Yeung,
Brian Hon-Yin Chung,
Sanaa Choufani,
Mo Yin Mok,
Wai Lap Wong,
Christopher Chun Yu Mak,
Wanling Yang,
Pamela Pui Wah Lee,
Wilfred Hing Sang Wong,
Yi-an Chen

Published: January 13, 2017
https://doi.org/10.1371/journal.pone.0169553

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