Mechanism of Collaborative Enhancement of Binding of Paired Antibodies to Distinct Epitopes of Platelet Endothelial Cell Adhesion Molecule-1

Raisa Kiseleva; Colin F. Greineder; Carlos H. Villa; Elizabeth D. Hood; Vladimir V. Shuvaev; Jing Sun; Ann-Marie Chacko; Valsamma Abraham; Horace M. DeLisser; Vladimir R. Muzykantov

doi:10.1371/journal.pone.0169537

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Peer-reviewed

Research Article

Mechanism of Collaborative Enhancement of Binding of Paired Antibodies to Distinct Epitopes of Platelet Endothelial Cell Adhesion Molecule-1

Raisa Kiseleva,

Affiliation Department of Pharmacology, The Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States of America

http://orcid.org/0000-0001-8065-3551

⨯
Colin F. Greineder,

Affiliation Department of Pharmacology, The Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States of America
⨯
Carlos H. Villa,

Affiliation Department of Pharmacology, The Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States of America
⨯
Elizabeth D. Hood,

Affiliation Department of Pharmacology, The Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States of America
⨯
Vladimir V. Shuvaev,

Affiliation Department of Pharmacology, The Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States of America
⨯
Jing Sun,

Affiliation Pulmonary, Allergy & Critical Care Division, The Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States of America
⨯
Ann-Marie Chacko,

Affiliation Laboratory for Translational and Molecular Imaging, Duke-NUS Medical School, Singapore, Republic of Singapore
⨯
Valsamma Abraham,

Affiliations Pulmonary, Allergy & Critical Care Division, The Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States of America, Corporal Michael J. Crescenz Veterans Affairs Medical Center in Philadelphia, PA, United States of America
⨯
Horace M. DeLisser,

Affiliations Pulmonary, Allergy & Critical Care Division, The Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States of America, Corporal Michael J. Crescenz Veterans Affairs Medical Center in Philadelphia, PA, United States of America
⨯
Vladimir R. Muzykantov

* E-mail: muzykant@mail.med.upenn.edu

Affiliation Department of Pharmacology, The Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States of America
⨯

Mechanism of Collaborative Enhancement of Binding of Paired Antibodies to Distinct Epitopes of Platelet Endothelial Cell Adhesion Molecule-1

Raisa Kiseleva,
Colin F. Greineder,
Carlos H. Villa,
Elizabeth D. Hood,
Vladimir V. Shuvaev,
Jing Sun,
Ann-Marie Chacko,
Valsamma Abraham,
Horace M. DeLisser,
Vladimir R. Muzykantov

Published: January 13, 2017
https://doi.org/10.1371/journal.pone.0169537

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Cell binding
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Cell binding assay
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Cell membranes
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Binding analysis
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Antibodies
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