Conjugated Linoleic Acid Administration Induces Amnesia in Male Sprague Dawley Rats and Exacerbates Recovery from Functional Deficits Induced by a Controlled Cortical Impact Injury

Rastafa I. Geddes; Kentaro Hayashi; Quinn Bongers; Marlyse Wehber; Icelle M. Anderson; Alex D. Jansen; Chase Nier; Emily Fares; Gabrielle Farquhar; Amita Kapoor; Toni E. Ziegler; Sivan VadakkadathMeethal; Ian M. Bird; Craig S. Atwood

doi:10.1371/journal.pone.0169494

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Research Article

Conjugated Linoleic Acid Administration Induces Amnesia in Male Sprague Dawley Rats and Exacerbates Recovery from Functional Deficits Induced by a Controlled Cortical Impact Injury

Rastafa I. Geddes,

Affiliation Division of Geriatrics and Gerontology, Department of Medicine, University of Wisconsin-Madison School of Medicine and Public Health, Wisconsin, United States of America
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Kentaro Hayashi,

Affiliation Division of Geriatrics and Gerontology, Department of Medicine, University of Wisconsin-Madison School of Medicine and Public Health, Wisconsin, United States of America
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Quinn Bongers,

Affiliation Division of Geriatrics and Gerontology, Department of Medicine, University of Wisconsin-Madison School of Medicine and Public Health, Wisconsin, United States of America
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Marlyse Wehber,

Affiliation Division of Geriatrics and Gerontology, Department of Medicine, University of Wisconsin-Madison School of Medicine and Public Health, Wisconsin, United States of America
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Icelle M. Anderson,

Affiliation Division of Geriatrics and Gerontology, Department of Medicine, University of Wisconsin-Madison School of Medicine and Public Health, Wisconsin, United States of America
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Alex D. Jansen,

Affiliation Division of Geriatrics and Gerontology, Department of Medicine, University of Wisconsin-Madison School of Medicine and Public Health, Wisconsin, United States of America
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Chase Nier,

Affiliation Division of Geriatrics and Gerontology, Department of Medicine, University of Wisconsin-Madison School of Medicine and Public Health, Wisconsin, United States of America
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Emily Fares,

Affiliation Division of Geriatrics and Gerontology, Department of Medicine, University of Wisconsin-Madison School of Medicine and Public Health, Wisconsin, United States of America
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Gabrielle Farquhar,

Affiliation Division of Geriatrics and Gerontology, Department of Medicine, University of Wisconsin-Madison School of Medicine and Public Health, Wisconsin, United States of America
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Amita Kapoor,

Affiliation Assay Services Unit and Institute for Clinical and Translational Research Core Laboratory, National Primate Research Center, University of Wisconsin-Madison, Wisconsin, United States of America
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Toni E. Ziegler,

Affiliation Assay Services Unit and Institute for Clinical and Translational Research Core Laboratory, National Primate Research Center, University of Wisconsin-Madison, Wisconsin, United States of America
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Sivan VadakkadathMeethal,

Affiliation Division of Geriatrics and Gerontology, Department of Medicine, University of Wisconsin-Madison School of Medicine and Public Health, Wisconsin, United States of America
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Ian M. Bird,

Affiliation Department of Obstetrics and Gynecology, University of Wisconsin-Madison School of Medicine and Public Health, Wisconsin, United States of America
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Craig S. Atwood

* E-mail: csa@medicine.wisc.edu

Affiliations Division of Geriatrics and Gerontology, Department of Medicine, University of Wisconsin-Madison School of Medicine and Public Health, Wisconsin, United States of America, Geriatric Research, Education and Clinical Center, Veterans Administration Hospital, Madison, Wisconsin, United States of America, School of Exercise, Biomedical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, Australia

http://orcid.org/0000-0001-5040-1679

⨯

Conjugated Linoleic Acid Administration Induces Amnesia in Male Sprague Dawley Rats and Exacerbates Recovery from Functional Deficits Induced by a Controlled Cortical Impact Injury

Rastafa I. Geddes,
Kentaro Hayashi,
Quinn Bongers,
Marlyse Wehber,
Icelle M. Anderson,
Alex D. Jansen,
Chase Nier,
Emily Fares,
Gabrielle Farquhar,
Amita Kapoor

Published: January 26, 2017
https://doi.org/10.1371/journal.pone.0169494

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