The Anti-Oxidant Ergothioneine Augments the Immunomodulatory Function of TLR Agonists by Direct Action on Macrophages

Sumito Yoshida; Hiroaki Shime; Kenji Funami; Hiromi Takaki; Misako Matsumoto; Masanori Kasahara; Tsukasa Seya

doi:10.1371/journal.pone.0169360

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Peer-reviewed

Research Article

The Anti-Oxidant Ergothioneine Augments the Immunomodulatory Function of TLR Agonists by Direct Action on Macrophages

Sumito Yoshida ,

Contributed equally to this work with: Sumito Yoshida, Hiroaki Shime

Affiliations Department of Microbiology and Immunology, Graduate School of Medicine, Hokkaido University, Kita-ku, Sapporo City, Japan, Department of Pathology I, Graduate School of Medicine, Hokkaido University, Kita-ku, Sapporo City, Japan
⨯
Hiroaki Shime ,

Contributed equally to this work with: Sumito Yoshida, Hiroaki Shime

Affiliation Department of Microbiology and Immunology, Graduate School of Medicine, Hokkaido University, Kita-ku, Sapporo City, Japan
⨯
Kenji Funami,

Affiliation Department of Microbiology and Immunology, Graduate School of Medicine, Hokkaido University, Kita-ku, Sapporo City, Japan
⨯
Hiromi Takaki,

Affiliation Department of Microbiology and Immunology, Graduate School of Medicine, Hokkaido University, Kita-ku, Sapporo City, Japan
⨯
Misako Matsumoto,

Affiliations Department of Microbiology and Immunology, Graduate School of Medicine, Hokkaido University, Kita-ku, Sapporo City, Japan, Department of Pathology I, Graduate School of Medicine, Hokkaido University, Kita-ku, Sapporo City, Japan
⨯
Masanori Kasahara,

Affiliation Department of Pathology I, Graduate School of Medicine, Hokkaido University, Kita-ku, Sapporo City, Japan
⨯
Tsukasa Seya

* E-mail: seya-tu@pop.med.hokudai.ac.jp

Affiliations Department of Microbiology and Immunology, Graduate School of Medicine, Hokkaido University, Kita-ku, Sapporo City, Japan, Department of Pathology I, Graduate School of Medicine, Hokkaido University, Kita-ku, Sapporo City, Japan
⨯

The Anti-Oxidant Ergothioneine Augments the Immunomodulatory Function of TLR Agonists by Direct Action on Macrophages

Sumito Yoshida,
Hiroaki Shime,
Kenji Funami,
Hiromi Takaki,
Misako Matsumoto,
Masanori Kasahara,
Tsukasa Seya

Published: January 23, 2017
https://doi.org/10.1371/journal.pone.0169360

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