ASC Induces Apoptosis via Activation of Caspase-9 by Enhancing Gap Junction-Mediated Intercellular Communication

Masato Kitazawa; Shigeaki Hida; Chifumi Fujii; Shun’ichiro Taniguchi; Kensuke Ito; Tomio Matsumura; Nagisa Okada; Takashi Sakaizawa; Akira Kobayashi; Michiko Takeoka; Shin-ichi Miyagawa

doi:10.1371/journal.pone.0169340

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Open Access

Peer-reviewed

Research Article

ASC Induces Apoptosis via Activation of Caspase-9 by Enhancing Gap Junction-Mediated Intercellular Communication

Masato Kitazawa ,

* E-mail: kita118@shinshu-u.ac.jp

Affiliations Department of Surgery, Shinshu University School of Medicine, Matsumoto, Japan, Department of Molecular Oncology, Shinshu University Graduate School of Medicine, Matsumoto, Japan

http://orcid.org/0000-0001-7737-7592

⨯
Shigeaki Hida,

Affiliation Department of Molecular and Cellular Health Science, Nagoya City University Graduate School of Pharmaceutical Sciences, Mizuho-ku, Nagoya, Japan
⨯
Chifumi Fujii,

Affiliation Department of Molecular Oncology, Shinshu University Graduate School of Medicine, Matsumoto, Japan
⨯
Shun’ichiro Taniguchi,

Affiliation Department of Molecular Oncology, Shinshu University Graduate School of Medicine, Matsumoto, Japan
⨯
Kensuke Ito,

Affiliation Department of Molecular Oncology, Shinshu University Graduate School of Medicine, Matsumoto, Japan
⨯
Tomio Matsumura,

Affiliation Department of Molecular Oncology, Shinshu University Graduate School of Medicine, Matsumoto, Japan
⨯
Nagisa Okada,

Affiliation Department of Molecular Oncology, Shinshu University Graduate School of Medicine, Matsumoto, Japan
⨯
Takashi Sakaizawa,

Affiliation Department of Surgery, Shinshu University School of Medicine, Matsumoto, Japan
⨯
Akira Kobayashi,

Affiliation Department of Surgery, Shinshu University School of Medicine, Matsumoto, Japan
⨯
Michiko Takeoka,

Affiliation Department of Surgery, Shinshu University School of Medicine, Matsumoto, Japan
⨯
Shin-ichi Miyagawa

Affiliation Department of Surgery, Shinshu University School of Medicine, Matsumoto, Japan
⨯

ASC Induces Apoptosis via Activation of Caspase-9 by Enhancing Gap Junction-Mediated Intercellular Communication

Masato Kitazawa,
Shigeaki Hida,
Chifumi Fujii,
Shun’ichiro Taniguchi,
Kensuke Ito,
Tomio Matsumura,
Nagisa Okada,
Takashi Sakaizawa,
Akira Kobayashi,
Michiko Takeoka

Published: January 5, 2017
https://doi.org/10.1371/journal.pone.0169340

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Gap junctions
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Cancers and neoplasms
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