Co-Targeting IGF-1R and Autophagy Enhances the Effects of Cell Growth Suppression and Apoptosis Induced by the IGF-1R Inhibitor NVP-AEW541 in Triple-Negative Breast Cancer Cells

Open Access

Peer-reviewed

Research Article

Weibin Wu ,

Contributed equally to this work with: Weibin Wu, Jieyi Ma

Affiliations Department of Breast Surgery, First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China, Department of Vascular Surgery, First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
⨯
Jieyi Ma ,

Contributed equally to this work with: Weibin Wu, Jieyi Ma

Affiliation Laboratory of General Surgery, First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
⨯
Nan Shao,

Affiliation Department of Breast Surgery, First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
⨯
Yawei Shi,

Affiliation Department of Breast Surgery, First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
⨯
Ruiming Liu,

Affiliation Laboratory of General Surgery, First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
⨯
Wen Li,

Affiliation Department of Vascular Surgery, First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
⨯
Yin Lin ,

* E-mail: shenmingwang@hotmail.com (SW); frostlin@hotmail.com (YL)

Affiliation Department of Breast Surgery, First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
⨯
Shenming Wang

* E-mail: shenmingwang@hotmail.com (SW); frostlin@hotmail.com (YL)

Affiliations Department of Breast Surgery, First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China, Department of Vascular Surgery, First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
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Autophagic cell death
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Breast cancer
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Small interfering RNA
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Cancer treatment
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Apoptosis
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Lung and intrathoracic tumors
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Hepatocellular carcinoma
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Cell cycle and cell division
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