An Experimental Analysis of the Molecular Effects of Trastuzumab (Herceptin) and Fulvestrant (Falsodex), as Single Agents or in Combination, on Human HR+/HER2+ Breast Cancer Cell Lines and Mouse Tumor Xenografts

Open Access

Peer-reviewed

Research Article

Qing Chen ,

Contributed equally to this work with: Qing Chen, Ziyi Weng

Affiliation Department of General Surgery, XinHua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
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Ziyi Weng ,

Contributed equally to this work with: Qing Chen, Ziyi Weng

Affiliation Department of General Surgery, Shanghai International Medical Center, Shanghai, China
⨯
Yunshu Lu,

Affiliation Department of General Surgery, XinHua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
⨯
Yijun Jia,

Affiliation Department of General Surgery, XinHua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
⨯
Longlong Ding,

Affiliation Department of General Surgery, XinHua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
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Fang Bai,

Affiliation Department of General Surgery, XinHua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
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Meixin Ge,

Affiliation Department of General Surgery, XinHua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China
⨯
Qing Lin ,

* E-mail: kejinwu1128@163.com (KW); linqing.linda@163.com (QL)

Affiliation Department of Radiation Oncology, The Shanghai Tenth People's Hospital of Tongji University, Shanghai, China
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Kejin Wu

* E-mail: kejinwu1128@163.com (KW); linqing.linda@163.com (QL)

Affiliation Department of Breast Surgery, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China
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Breast cancer
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Apoptosis
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BT474 cells
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Cell cycle and cell division
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Endocrine therapy
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Mouse models
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