Pharmaceutical Metabolism in Fish: Using a 3-D Hepatic In Vitro Model to Assess Clearance

• Matthew G. Baron,

  Affiliations School of Biological Science, Plymouth University, Devon, United Kingdom, AstraZeneca, Alderley Park, Macclesfield, Cheshire, United Kingdom

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• Kate S. Mintram,

  Affiliations School of Biological Science, Plymouth University, Devon, United Kingdom, AstraZeneca, Alderley Park, Macclesfield, Cheshire, United Kingdom

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• Stewart F. Owen ,

  * E-mail: Stewart.Owen@AstraZeneca.com (SFO); a.jha@plymouth.ac.uk (ANJ)

  Affiliation AstraZeneca, Alderley Park, Macclesfield, Cheshire, United Kingdom

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• Malcolm J. Hetheridge,

  Affiliation AstraZeneca, Alderley Park, Macclesfield, Cheshire, United Kingdom

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• A. John Moody,

  Affiliation School of Biological Science, Plymouth University, Devon, United Kingdom

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• Wendy M. Purcell,

  Affiliation School of Biomedical & Healthcare Science, Plymouth University, Devon, United Kingdom

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• Simon K. Jackson,

  Affiliation School of Biomedical & Healthcare Science, Plymouth University, Devon, United Kingdom

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• Awadhesh N. Jha

  * E-mail: Stewart.Owen@AstraZeneca.com (SFO); a.jha@plymouth.ac.uk (ANJ)

  Affiliation School of Biological Science, Plymouth University, Devon, United Kingdom

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