Altered Epithelial Gene Expression in Peripheral Airways of Severe Asthma

Akul Singhania; Hitasha Rupani; Nivenka Jayasekera; Simon Lumb; Paul Hales; Neil Gozzard; Donna E. Davies; Christopher H. Woelk; Peter H. Howarth

doi:10.1371/journal.pone.0168680

Loading metrics

Open Access

Peer-reviewed

Research Article

Altered Epithelial Gene Expression in Peripheral Airways of Severe Asthma

Akul Singhania,

Affiliation Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, United Kingdom
⨯
Hitasha Rupani,

Affiliation Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, United Kingdom
⨯
Nivenka Jayasekera,

Affiliation Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, United Kingdom
⨯
Simon Lumb,

Affiliation UCB Celltech, Slough, United Kingdom
⨯
Paul Hales,

Affiliation UCB Celltech, Slough, United Kingdom
⨯
Neil Gozzard,

Affiliation UCB Celltech, Slough, United Kingdom
⨯
Donna E. Davies,

Affiliations Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, United Kingdom, Southampton NIHR Respiratory Biomedical Research Unit, Southampton Centre for Biomedical Research, University Hospital Southampton NHS Foundation Trust, Southampton, United Kingdom
⨯
Christopher H. Woelk ,

Contributed equally to this work with: Christopher H. Woelk, Peter H. Howarth

* E-mail: c.h.woelk@soton.ac.uk (CHH); p.h.howarth@soton.ac.uk (PHH)

Affiliation Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, United Kingdom
⨯
Peter H. Howarth

Contributed equally to this work with: Christopher H. Woelk, Peter H. Howarth

* E-mail: c.h.woelk@soton.ac.uk (CHH); p.h.howarth@soton.ac.uk (PHH)

Affiliations Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, United Kingdom, Southampton NIHR Respiratory Biomedical Research Unit, Southampton Centre for Biomedical Research, University Hospital Southampton NHS Foundation Trust, Southampton, United Kingdom
⨯

Altered Epithelial Gene Expression in Peripheral Airways of Severe Asthma

Akul Singhania,
Hitasha Rupani,
Nivenka Jayasekera,
Simon Lumb,
Paul Hales,
Neil Gozzard,
Donna E. Davies,
Christopher H. Woelk,
Peter H. Howarth

Published: January 3, 2017
https://doi.org/10.1371/journal.pone.0168680

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Asthma
Is the Subject Area "Asthma" applicable to this article?

Thanks for your feedback.
Gene expression
Is the Subject Area "Gene expression" applicable to this article?

Thanks for your feedback.
Steroid therapy
Is the Subject Area "Steroid therapy" applicable to this article?

Thanks for your feedback.
Mast cells
Is the Subject Area "Mast cells" applicable to this article?

Thanks for your feedback.
Microarrays
Is the Subject Area "Microarrays" applicable to this article?

Thanks for your feedback.
Fibroblast growth factor
Is the Subject Area "Fibroblast growth factor" applicable to this article?

Thanks for your feedback.
Epithelial cells
Is the Subject Area "Epithelial cells" applicable to this article?

Thanks for your feedback.
Principal component analysis
Is the Subject Area "Principal component analysis" applicable to this article?

Thanks for your feedback.