Structural Studies of a Rationally Selected Multi-Drug Resistant HIV-1 Protease Reveal Synergistic Effect of Distal Mutations on Flap Dynamics

• Johnson Agniswamy,

  Affiliation Department of Biology, Georgia State University, Atlanta, Georgia, United States of America

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• John M. Louis,

  Affiliation Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, DHHS, Bethesda, Maryland, United States of America

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• Julien Roche,

  Affiliations Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, DHHS, Bethesda, Maryland, United States of America, Roy J. Carver Department of Biochemistry, Biophysics and Molecular Biology, Iowa State University, Ames, Iowa, United States of America

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• Robert W. Harrison,

  Affiliations Department of Biology, Georgia State University, Atlanta, Georgia, United States of America, Department of Computer Science, Georgia State University, Atlanta, Georgia, United States of America

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• Irene T. Weber

  * E-mail: iweber@gsu.edu

  Affiliations Department of Biology, Georgia State University, Atlanta, Georgia, United States of America, Department of Chemistry, Georgia State University, Atlanta, Georgia, United States of America

  http://orcid.org/0000-0003-4876-7393

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