A Small Molecule Inhibitor of Sarcomere Contractility Acutely Relieves Left Ventricular Outflow Tract Obstruction in Feline Hypertrophic Cardiomyopathy

• Joshua A. Stern,

  Affiliation Department of Medicine & Epidemiology, School of Veterinary Medicine, University of California Davis, Davis, California, United States of America

  ⨯
• Svetlana Markova,

  Affiliation MyoKardia, Inc., South San Francisco, California, United States of America

  ⨯
• Yu Ueda,

  Affiliation Department of Medicine & Epidemiology, School of Veterinary Medicine, University of California Davis, Davis, California, United States of America

  ⨯
• Jae B. Kim,

  Current address: Alnylam Pharmaceuticals, Cambridge, Massachusetts, United States of America

  Affiliation MyoKardia, Inc., South San Francisco, California, United States of America

  ⨯
• Peter J. Pascoe,

  Affiliation Department of Surgical & Radiological Sciences, School of Veterinary Medicine, University of California Davis, Davis, California, United States of America

  ⨯
• Marc J. Evanchik,

  Affiliation MyoKardia, Inc., South San Francisco, California, United States of America

  ⨯
• Eric M. Green ,

  * E-mail: samharris@email.arizona.edu (SPH); egreen@myokardia.com (EMG)

  ¶‡ Joint Senior Authors.

  Affiliation MyoKardia, Inc., South San Francisco, California, United States of America

  ⨯
• Samantha P. Harris

  * E-mail: samharris@email.arizona.edu (SPH); egreen@myokardia.com (EMG)

  ¶‡ Joint Senior Authors.

  Affiliation Department of Cellular and Molecular Medicine, College of Medicine, University of Arizona, Tucson, Arizona, United States of America

  ⨯