Alterations in Gut Microbiome Composition and Barrier Function Are Associated with Reproductive and Metabolic Defects in Women with Polycystic Ovary Syndrome (PCOS): A Pilot Study

Lisa Lindheim; Mina Bashir; Julia Münzker; Christian Trummer; Verena Zachhuber; Bettina Leber; Angela Horvath; Thomas R. Pieber; Gregor Gorkiewicz; Vanessa Stadlbauer; Barbara Obermayer-Pietsch

doi:10.1371/journal.pone.0168390

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Open Access

Peer-reviewed

Research Article

Alterations in Gut Microbiome Composition and Barrier Function Are Associated with Reproductive and Metabolic Defects in Women with Polycystic Ovary Syndrome (PCOS): A Pilot Study

Lisa Lindheim ,

* E-mail: lisa.lindheim@medunigraz.at

Affiliation Department of Internal Medicine, Division of Endocrinology and Diabetology, Medical University Graz, Graz, Austria

http://orcid.org/0000-0001-7732-3869

⨯
Mina Bashir,

Affiliation Department of Internal Medicine, Division of Endocrinology and Diabetology, Medical University Graz, Graz, Austria
⨯
Julia Münzker,

Affiliation Department of Internal Medicine, Division of Endocrinology and Diabetology, Medical University Graz, Graz, Austria
⨯
Christian Trummer,

Affiliation Department of Internal Medicine, Division of Endocrinology and Diabetology, Medical University Graz, Graz, Austria
⨯
Verena Zachhuber,

Affiliation Department of Internal Medicine, Division of Endocrinology and Diabetology, Medical University Graz, Graz, Austria
⨯
Bettina Leber,

Affiliations Department of Surgery, Division of Transplantation Surgery, Medical University Graz, Graz, Austria, Center for Biomarker Research in Medicine (CBmed), Graz, Austria
⨯
Angela Horvath,

Affiliation Department of Internal Medicine, Division of Gastroenterology and Hepatology, Medical University Graz, Graz, Austria
⨯
Thomas R. Pieber,

Affiliations Department of Internal Medicine, Division of Endocrinology and Diabetology, Medical University Graz, Graz, Austria, Center for Biomarker Research in Medicine (CBmed), Graz, Austria
⨯
Gregor Gorkiewicz,

Affiliations Institute of Pathology, Medical University Graz, Graz, Austria, BioTechMed, Interuniversity Cooperation, Graz, Austria
⨯
Vanessa Stadlbauer,

Affiliations Center for Biomarker Research in Medicine (CBmed), Graz, Austria, Department of Internal Medicine, Division of Gastroenterology and Hepatology, Medical University Graz, Graz, Austria
⨯
Barbara Obermayer-Pietsch

Affiliations Department of Internal Medicine, Division of Endocrinology and Diabetology, Medical University Graz, Graz, Austria, Center for Biomarker Research in Medicine (CBmed), Graz, Austria
⨯

Alterations in Gut Microbiome Composition and Barrier Function Are Associated with Reproductive and Metabolic Defects in Women with Polycystic Ovary Syndrome (PCOS): A Pilot Study

Lisa Lindheim,
Mina Bashir,
Julia Münzker,
Christian Trummer,
Verena Zachhuber,
Bettina Leber,
Angela Horvath,
Thomas R. Pieber,
Gregor Gorkiewicz,
Vanessa Stadlbauer

Published: January 3, 2017
https://doi.org/10.1371/journal.pone.0168390

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