Hedgehog Signaling Overcomes an EZH2-Dependent Epigenetic Barrier to Promote Cholangiocyte Expansion

Nidhi Jalan-Sakrikar; Thiago M. De Assuncao; Jie Lu; Luciana L. Almada; Gwen Lomberk; Martin E. Fernandez-Zapico; Raul Urrutia; Robert C. Huebert

doi:10.1371/journal.pone.0168266

Loading metrics

Open Access

Peer-reviewed

Research Article

Hedgehog Signaling Overcomes an EZH2-Dependent Epigenetic Barrier to Promote Cholangiocyte Expansion

Nidhi Jalan-Sakrikar ,

Contributed equally to this work with: Nidhi Jalan-Sakrikar, Thiago M. De Assuncao

Affiliations Division of Gastroenterology and Hepatology, Mayo Clinic and Foundation, Rochester, MN, United States of America, Gastroenterology Research Unit, Mayo Clinic and Foundation, Rochester, MN, United States of America
⨯
Thiago M. De Assuncao ,

Contributed equally to this work with: Nidhi Jalan-Sakrikar, Thiago M. De Assuncao

Affiliations Division of Gastroenterology and Hepatology, Mayo Clinic and Foundation, Rochester, MN, United States of America, Gastroenterology Research Unit, Mayo Clinic and Foundation, Rochester, MN, United States of America
⨯
Jie Lu,

Affiliations Division of Gastroenterology and Hepatology, Mayo Clinic and Foundation, Rochester, MN, United States of America, Gastroenterology Research Unit, Mayo Clinic and Foundation, Rochester, MN, United States of America
⨯
Luciana L. Almada,

Affiliation Schultze Center for Novel Therapeutics, Mayo Clinic and Foundation, Rochester, MN, United States of America
⨯
Gwen Lomberk,

Affiliations Division of Gastroenterology and Hepatology, Mayo Clinic and Foundation, Rochester, MN, United States of America, Gastroenterology Research Unit, Mayo Clinic and Foundation, Rochester, MN, United States of America, Center for Cell Signaling in Gastroenterology, Mayo Clinic and Foundation, Rochester, MN, United States of America
⨯
Martin E. Fernandez-Zapico,

Affiliations Schultze Center for Novel Therapeutics, Mayo Clinic and Foundation, Rochester, MN, United States of America, Center for Cell Signaling in Gastroenterology, Mayo Clinic and Foundation, Rochester, MN, United States of America
⨯
Raul Urrutia,

Affiliations Division of Gastroenterology and Hepatology, Mayo Clinic and Foundation, Rochester, MN, United States of America, Gastroenterology Research Unit, Mayo Clinic and Foundation, Rochester, MN, United States of America, Center for Cell Signaling in Gastroenterology, Mayo Clinic and Foundation, Rochester, MN, United States of America
⨯
Robert C. Huebert

* E-mail: huebert.robert@mayo.edu

Affiliations Division of Gastroenterology and Hepatology, Mayo Clinic and Foundation, Rochester, MN, United States of America, Gastroenterology Research Unit, Mayo Clinic and Foundation, Rochester, MN, United States of America, Center for Cell Signaling in Gastroenterology, Mayo Clinic and Foundation, Rochester, MN, United States of America
⨯

Hedgehog Signaling Overcomes an EZH2-Dependent Epigenetic Barrier to Promote Cholangiocyte Expansion

Nidhi Jalan-Sakrikar,
Thiago M. De Assuncao,
Jie Lu,
Luciana L. Almada,
Gwen Lomberk,
Martin E. Fernandez-Zapico,
Raul Urrutia,
Robert C. Huebert

Published: December 9, 2016
https://doi.org/10.1371/journal.pone.0168266

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Cell differentiation
Is the Subject Area "Cell differentiation" applicable to this article?

Thanks for your feedback.
Epigenetics
Is the Subject Area "Epigenetics" applicable to this article?

Thanks for your feedback.
Gene expression
Is the Subject Area "Gene expression" applicable to this article?

Thanks for your feedback.
Induced pluripotent stem cells
Is the Subject Area "Induced pluripotent stem cells" applicable to this article?

Thanks for your feedback.
Fibrosis
Is the Subject Area "Fibrosis" applicable to this article?

Thanks for your feedback.
RNA sequencing
Is the Subject Area "RNA sequencing" applicable to this article?

Thanks for your feedback.
Mouse models
Is the Subject Area "Mouse models" applicable to this article?

Thanks for your feedback.
Hepatocytes
Is the Subject Area "Hepatocytes" applicable to this article?

Thanks for your feedback.