GSK-3β/NFAT Signaling Is Involved in Testosterone-Induced Cardiac Myocyte Hypertrophy

Javier Duran; Cesar Oyarce; Mario Pavez; Denisse Valladares; Carla Basualto-Alarcon; Daniel Lagos; Genaro Barrientos; Mayarling Francisca Troncoso; Cristian Ibarra; Manuel Estrada

doi:10.1371/journal.pone.0168255

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Open Access

Peer-reviewed

Research Article

GSK-3β/NFAT Signaling Is Involved in Testosterone-Induced Cardiac Myocyte Hypertrophy

Javier Duran,

Affiliation Laboratorio de Endocrinología Celular, Programa de Fisiología y Biofísica, Instituto de Ciencias Biomédicas, Facultad de Medicina, Universidad de Chile, Santiago, Chile
⨯
Cesar Oyarce,

Affiliation Laboratorio de Endocrinología Celular, Programa de Fisiología y Biofísica, Instituto de Ciencias Biomédicas, Facultad de Medicina, Universidad de Chile, Santiago, Chile
⨯
Mario Pavez,

Affiliation Laboratorio de Endocrinología Celular, Programa de Fisiología y Biofísica, Instituto de Ciencias Biomédicas, Facultad de Medicina, Universidad de Chile, Santiago, Chile
⨯
Denisse Valladares,

Affiliation Laboratorio de Endocrinología Celular, Programa de Fisiología y Biofísica, Instituto de Ciencias Biomédicas, Facultad de Medicina, Universidad de Chile, Santiago, Chile
⨯
Carla Basualto-Alarcon,

Affiliation Programa de Anatomía y Biología del Desarrollo, Instituto de Ciencias Biomédicas, Facultad de Medicina, Universidad de Chile, Santiago, Chile
⨯
Daniel Lagos,

Affiliation Laboratorio de Endocrinología Celular, Programa de Fisiología y Biofísica, Instituto de Ciencias Biomédicas, Facultad de Medicina, Universidad de Chile, Santiago, Chile
⨯
Genaro Barrientos,

Affiliation Laboratorio de Endocrinología Celular, Programa de Fisiología y Biofísica, Instituto de Ciencias Biomédicas, Facultad de Medicina, Universidad de Chile, Santiago, Chile
⨯
Mayarling Francisca Troncoso,

Affiliation Laboratorio de Endocrinología Celular, Programa de Fisiología y Biofísica, Instituto de Ciencias Biomédicas, Facultad de Medicina, Universidad de Chile, Santiago, Chile
⨯
Cristian Ibarra,

Affiliation Heart Failure Bioscience Department, Cardiovascular and Metabolic Diseases (CVMD), Innovative Medicines & Early Development iMED Biotech unit, AstraZeneca R&D, Mölndal, Sweden
⨯
Manuel Estrada

* E-mail: iestrada@med.uchile.cl

Affiliation Laboratorio de Endocrinología Celular, Programa de Fisiología y Biofísica, Instituto de Ciencias Biomédicas, Facultad de Medicina, Universidad de Chile, Santiago, Chile

http://orcid.org/0000-0001-7877-8160

⨯

GSK-3β/NFAT Signaling Is Involved in Testosterone-Induced Cardiac Myocyte Hypertrophy

Javier Duran,
Cesar Oyarce,
Mario Pavez,
Denisse Valladares,
Carla Basualto-Alarcon,
Daniel Lagos,
Genaro Barrientos,
Mayarling Francisca Troncoso,
Cristian Ibarra,
Manuel Estrada

Published: December 15, 2016
https://doi.org/10.1371/journal.pone.0168255

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Testosterone
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Muscle cells
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Phosphorylation
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Transfection
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Androgens
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Small interfering RNA
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Cardiac hypertrophy
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Calcineurin signaling cascade
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