Pathophysiological Consequences of a Break in S1P1-Dependent Homeostasis of Vascular Permeability Revealed by S1P1 Competitive Antagonism

Marc Bigaud; Zuhal Dincer; Birgit Bollbuck; Janet Dawson; Nicolau Beckmann; Christian Beerli; Gina Fishli-Cavelti; Michaela Nahler; Daniela Angst; Philipp Janser; Heike Otto; Elisabeth Rosner; Rene Hersperger; Christian Bruns; Jean Quancard

doi:10.1371/journal.pone.0168252

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Open Access

Peer-reviewed

Research Article

Pathophysiological Consequences of a Break in S1P1-Dependent Homeostasis of Vascular Permeability Revealed by S1P1 Competitive Antagonism

Marc Bigaud ,

* E-mail: marc.bigaud@novartis.com

Affiliation Novartis Institutes for Biomedical Research, Autoimmunity, Transplantation and Inflammation, Basel, Switzerland
⨯
Zuhal Dincer,

Affiliation Novartis Institutes for Biomedical Research, Autoimmunity, Transplantation and Inflammation, Basel, Switzerland
⨯
Birgit Bollbuck,

Affiliation Novartis Institutes for Biomedical Research, Autoimmunity, Transplantation and Inflammation, Basel, Switzerland
⨯
Janet Dawson,

Affiliation Novartis Institutes for Biomedical Research, Autoimmunity, Transplantation and Inflammation, Basel, Switzerland
⨯
Nicolau Beckmann,

Affiliation Novartis Institutes for Biomedical Research, Autoimmunity, Transplantation and Inflammation, Basel, Switzerland
⨯
Christian Beerli,

Affiliation Novartis Institutes for Biomedical Research, Autoimmunity, Transplantation and Inflammation, Basel, Switzerland
⨯
Gina Fishli-Cavelti,

Affiliation Novartis Institutes for Biomedical Research, Autoimmunity, Transplantation and Inflammation, Basel, Switzerland
⨯
Michaela Nahler,

Affiliation Novartis Institutes for Biomedical Research, Autoimmunity, Transplantation and Inflammation, Basel, Switzerland
⨯
Daniela Angst,

Affiliation Novartis Institutes for Biomedical Research, Autoimmunity, Transplantation and Inflammation, Basel, Switzerland
⨯
Philipp Janser,

Affiliation Novartis Institutes for Biomedical Research, Autoimmunity, Transplantation and Inflammation, Basel, Switzerland
⨯
Heike Otto,

Affiliation Novartis Institutes for Biomedical Research, Autoimmunity, Transplantation and Inflammation, Basel, Switzerland
⨯
Elisabeth Rosner,

Affiliation Novartis Institutes for Biomedical Research, Autoimmunity, Transplantation and Inflammation, Basel, Switzerland
⨯
Rene Hersperger,

Affiliation Novartis Institutes for Biomedical Research, Autoimmunity, Transplantation and Inflammation, Basel, Switzerland
⨯
Christian Bruns,

Affiliation Novartis Institutes for Biomedical Research, Autoimmunity, Transplantation and Inflammation, Basel, Switzerland
⨯
Jean Quancard

Affiliation Novartis Institutes for Biomedical Research, Autoimmunity, Transplantation and Inflammation, Basel, Switzerland
⨯

Pathophysiological Consequences of a Break in S1P1-Dependent Homeostasis of Vascular Permeability Revealed by S1P1 Competitive Antagonism

Marc Bigaud,
Zuhal Dincer,
Birgit Bollbuck,
Janet Dawson,
Nicolau Beckmann,
Christian Beerli,
Gina Fishli-Cavelti,
Michaela Nahler,
Daniela Angst,
Philipp Janser

Published: December 22, 2016
https://doi.org/10.1371/journal.pone.0168252

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