68Ga-TRAP-(RGD)3 Hybrid Imaging for the In Vivo Monitoring of αvß3-Integrin Expression as Biomarker of Anti-Angiogenic Therapy Effects in Experimental Breast Cancer

Philipp M. Kazmierczak; Andrei Todica; Franz-Josef Gildehaus; Heidrun Hirner-Eppeneder; Matthias Brendel; Ralf S. Eschbach; Magdalena Hellmann; Konstantin Nikolaou; Maximilian F. Reiser; Hans-Jürgen Wester; Saskia Kropf; Axel Rominger; Clemens C. Cyran

doi:10.1371/journal.pone.0168248

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Open Access

Peer-reviewed

Research Article

⁶⁸Ga-TRAP-(RGD)₃ Hybrid Imaging for the In Vivo Monitoring of α_vß₃-Integrin Expression as Biomarker of Anti-Angiogenic Therapy Effects in Experimental Breast Cancer

Philipp M. Kazmierczak ,

* E-mail: philipp.kazmierczak@med.lmu.de

Affiliation Institute for Clinical Radiology, Laboratory for Experimental Radiology, Ludwig-Maximilians-University Hospital Munich, München, Germany
⨯
Andrei Todica,

Affiliation Department of Nuclear Medicine, Ludwig-Maximilians-University Hospital Munich, München, Germany
⨯
Franz-Josef Gildehaus,

Affiliation Department of Nuclear Medicine, Ludwig-Maximilians-University Hospital Munich, München, Germany
⨯
Heidrun Hirner-Eppeneder,

Affiliation Institute for Clinical Radiology, Laboratory for Experimental Radiology, Ludwig-Maximilians-University Hospital Munich, München, Germany
⨯
Matthias Brendel,

Affiliation Department of Nuclear Medicine, Ludwig-Maximilians-University Hospital Munich, München, Germany
⨯
Ralf S. Eschbach,

Affiliation Institute for Clinical Radiology, Laboratory for Experimental Radiology, Ludwig-Maximilians-University Hospital Munich, München, Germany
⨯
Magdalena Hellmann,

Affiliation Institute for Clinical Radiology, Laboratory for Experimental Radiology, Ludwig-Maximilians-University Hospital Munich, München, Germany
⨯
Konstantin Nikolaou,

Affiliation Department of Diagnostic and Interventional Radiology, University Hospital Tübingen, Tübingen, Germany
⨯
Maximilian F. Reiser,

Affiliation Institute for Clinical Radiology, Laboratory for Experimental Radiology, Ludwig-Maximilians-University Hospital Munich, München, Germany
⨯
Hans-Jürgen Wester,

Affiliation Lehrstuhl für Pharmazeutische Radiochemie, Technical University Munich, München, Germany
⨯
Saskia Kropf,

Affiliation SCINTOMICS GmbH, Fürstenfeldbruck, Germany
⨯
Axel Rominger,

Affiliation Department of Nuclear Medicine, Ludwig-Maximilians-University Hospital Munich, München, Germany
⨯
Clemens C. Cyran

Affiliation Institute for Clinical Radiology, Laboratory for Experimental Radiology, Ludwig-Maximilians-University Hospital Munich, München, Germany
⨯

⁶⁸Ga-TRAP-(RGD)₃ Hybrid Imaging for the In Vivo Monitoring of α_vß₃-Integrin Expression as Biomarker of Anti-Angiogenic Therapy Effects in Experimental Breast Cancer

Philipp M. Kazmierczak,
Andrei Todica,
Franz-Josef Gildehaus,
Heidrun Hirner-Eppeneder,
Matthias Brendel,
Ralf S. Eschbach,
Magdalena Hellmann,
Konstantin Nikolaou,
Maximilian F. Reiser,
Hans-Jürgen Wester

Published: December 19, 2016
https://doi.org/10.1371/journal.pone.0168248

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Breast cancer
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Cancers and neoplasms
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In vivo imaging
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Cancer treatment
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Autoradiography
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Immunohistochemistry techniques
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