Clock Genes Regulate the Circadian Expression of Piezo1, TRPV4, Connexin26, and VNUT in an Ex Vivo Mouse Bladder Mucosa

Tatsuya Ihara; Takahiko Mitsui; Yuki Nakamura; Satoru Kira; Hiroshi Nakagomi; Norifumi Sawada; Yuri Hirayama; Keisuke Shibata; Eiji Shigetomi; Yoichi Shinozaki; Mitsuharu Yoshiyama; Karl-Erik Andersson; Atsuhito Nakao; Masayuki Takeda; Schuichi Koizumi

doi:10.1371/journal.pone.0168234

Loading metrics

Open Access

Peer-reviewed

Research Article

Clock Genes Regulate the Circadian Expression of Piezo1, TRPV4, Connexin26, and VNUT in an Ex Vivo Mouse Bladder Mucosa

Tatsuya Ihara,

Affiliation Department of Urology, Interdisciplinary Graduate School of Medicine, University of Yamanashi, Chuo, Yamanashi, Japan
⨯
Takahiko Mitsui,

Affiliation Department of Urology, Interdisciplinary Graduate School of Medicine, University of Yamanashi, Chuo, Yamanashi, Japan
⨯
Yuki Nakamura,

Affiliation Department of Immunology, Interdisciplinary Graduate School of Medicine, University of Yamanashi, Chuo, Yamanashi, Japan
⨯
Satoru Kira,

Affiliation Department of Urology, Interdisciplinary Graduate School of Medicine, University of Yamanashi, Chuo, Yamanashi, Japan
⨯
Hiroshi Nakagomi,

Affiliation Department of Urology, Interdisciplinary Graduate School of Medicine, University of Yamanashi, Chuo, Yamanashi, Japan
⨯
Norifumi Sawada,

Affiliation Department of Urology, Interdisciplinary Graduate School of Medicine, University of Yamanashi, Chuo, Yamanashi, Japan
⨯
Yuri Hirayama,

Affiliation Department of Neuropharmacology, Interdisciplinary Graduate School of Medicine, University of Yamanashi, Chuo, Yamanashi, Japan
⨯
Keisuke Shibata,

Affiliation Department of Neuropharmacology, Interdisciplinary Graduate School of Medicine, University of Yamanashi, Chuo, Yamanashi, Japan
⨯
Eiji Shigetomi,

Affiliation Department of Neuropharmacology, Interdisciplinary Graduate School of Medicine, University of Yamanashi, Chuo, Yamanashi, Japan
⨯
Yoichi Shinozaki,

Affiliation Department of Neuropharmacology, Interdisciplinary Graduate School of Medicine, University of Yamanashi, Chuo, Yamanashi, Japan
⨯
Mitsuharu Yoshiyama,

Affiliation Department of Urology, Interdisciplinary Graduate School of Medicine, University of Yamanashi, Chuo, Yamanashi, Japan
⨯
Karl-Erik Andersson,

Affiliation Wake Forest University, Institute for Regenerative Medicine, Winston-Salem, North Carolina, United State of America
⨯
Atsuhito Nakao,

Affiliation Department of Immunology, Interdisciplinary Graduate School of Medicine, University of Yamanashi, Chuo, Yamanashi, Japan
⨯
Masayuki Takeda ,

* E-mail: skoizumi@yamanashi.ac.jp (SK); matakeda@yamanashi.ac.jp (MT)

Affiliation Department of Urology, Interdisciplinary Graduate School of Medicine, University of Yamanashi, Chuo, Yamanashi, Japan
⨯
Schuichi Koizumi

* E-mail: skoizumi@yamanashi.ac.jp (SK); matakeda@yamanashi.ac.jp (MT)

Affiliation Department of Neuropharmacology, Interdisciplinary Graduate School of Medicine, University of Yamanashi, Chuo, Yamanashi, Japan

http://orcid.org/0000-0001-6184-3106

⨯

Clock Genes Regulate the Circadian Expression of Piezo1, TRPV4, Connexin26, and VNUT in an Ex Vivo Mouse Bladder Mucosa

Tatsuya Ihara,
Takahiko Mitsui,
Yuki Nakamura,
Satoru Kira,
Hiroshi Nakagomi,
Norifumi Sawada,
Yuri Hirayama,
Keisuke Shibata,
Eiji Shigetomi,
Yoichi Shinozaki

Published: January 6, 2017
https://doi.org/10.1371/journal.pone.0168234

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Bladder
Is the Subject Area "Bladder" applicable to this article?

Thanks for your feedback.
Circadian rhythms
Is the Subject Area "Circadian rhythms" applicable to this article?

Thanks for your feedback.
Gene expression
Is the Subject Area "Gene expression" applicable to this article?

Thanks for your feedback.
Circadian oscillators
Is the Subject Area "Circadian oscillators" applicable to this article?

Thanks for your feedback.
Messenger RNA
Is the Subject Area "Messenger RNA" applicable to this article?

Thanks for your feedback.
Transcription factors
Is the Subject Area "Transcription factors" applicable to this article?

Thanks for your feedback.
Protein expression
Is the Subject Area "Protein expression" applicable to this article?

Thanks for your feedback.
Gene regulation
Is the Subject Area "Gene regulation" applicable to this article?

Thanks for your feedback.