The Effects of Ca2+ Concentration and E200K Mutation on the Aggregation Propensity of PrPC: A Computational Study

Open Access

Peer-reviewed

Research Article

The Effects of Ca²⁺ Concentration and E200K Mutation on the Aggregation Propensity of PrP^C: A Computational Study

Alessandro Marrone ,

* E-mail: amarrone@unich.it

Affiliation Università “G d’Annunzio” di Chieti-Pescara, Department of Pharmacy, Chieti, Italy

http://orcid.org/0000-0002-8311-8172

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Nazzareno Re,

Affiliation Università “G d’Annunzio” di Chieti-Pescara, Department of Pharmacy, Chieti, Italy
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Loriano Storchi

Affiliations Università “G d’Annunzio” di Chieti-Pescara, Department of Pharmacy, Chieti, Italy, Molecular Discovery Limited, Middlesex, London, United Kingdom
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Electrostatics
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Molecular dynamics
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Molecular self assembly
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Protein structure
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Mutation detection
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Binding analysis
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Free energy
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Protein interactions
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