Experimental Evolution of Mycobacterium tuberculosis in Human Macrophages Results in Low-Frequency Mutations Not Associated with Selective Advantage

• Valentina Guerrini,

  Affiliations Public Health Research Institute, New Jersey Medical School, Rutgers, The State University of New Jersey, Newark, New Jersey, United States of America, Laboratory of Molecular Microbiology and Biotechnology, Department of Medical Biotechnologies, University of Siena, Siena, Italy

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• Selvakumar Subbian,

  Affiliation Public Health Research Institute, New Jersey Medical School, Rutgers, The State University of New Jersey, Newark, New Jersey, United States of America

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• Pierre Santucci,

  Affiliation Aix-Marseille Univ, Centre National de la Recherche Scientifique, Laboratoire d'Enzymologie Interfaciale et de Physiologie de la Lipolyse, Marseille, France

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• Stéphane Canaan,

  Affiliation Aix-Marseille Univ, Centre National de la Recherche Scientifique, Laboratoire d'Enzymologie Interfaciale et de Physiologie de la Lipolyse, Marseille, France

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• Maria Laura Gennaro ,

  * E-mail: marila.gennaro@rutgers.edu

  Affiliation Public Health Research Institute, New Jersey Medical School, Rutgers, The State University of New Jersey, Newark, New Jersey, United States of America

  http://orcid.org/0000-0003-4801-3567

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• Gianni Pozzi

  Affiliation Laboratory of Molecular Microbiology and Biotechnology, Department of Medical Biotechnologies, University of Siena, Siena, Italy

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