Overexpression of TIMP-3 in Chondrocytes Produces Transient Reduction in Growth Plate Length but Permanently Reduces Adult Bone Quality and Quantity

Blandine Poulet; Ke Liu; Darren Plumb; Phoung Vo; Mittal Shah; Katherine Staines; Alexandra Sampson; Hiroyuki Nakamura; Hideaki Nagase; Alessandra Carriero; Sandra Shefelbine; Andrew A. Pitsillides; George Bou-Gharios

doi:10.1371/journal.pone.0167971

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Open Access

Peer-reviewed

Research Article

Overexpression of TIMP-3 in Chondrocytes Produces Transient Reduction in Growth Plate Length but Permanently Reduces Adult Bone Quality and Quantity

Blandine Poulet,

Affiliation Department of Musculoskeletal Biology, Institute of Ageing and Chronic Disease, University of Liverpool, Apex building, Liverpool, United Kingdom

http://orcid.org/0000-0002-9224-5253

⨯
Ke Liu,

Affiliation Department of Musculoskeletal Biology, Institute of Ageing and Chronic Disease, University of Liverpool, Apex building, Liverpool, United Kingdom

http://orcid.org/0000-0003-3769-1653

⨯
Darren Plumb,

Affiliation Department of Musculoskeletal Biology, Institute of Ageing and Chronic Disease, University of Liverpool, Apex building, Liverpool, United Kingdom
⨯
Phoung Vo,

Affiliation Kennedy Institute of Rheumatology, Oxford, United Kingdom
⨯
Mittal Shah,

Affiliation Comparative Biomedical Sciences, The Royal Veterinary College, London, United Kingdom
⨯
Katherine Staines,

Affiliation Comparative Biomedical Sciences, The Royal Veterinary College, London, United Kingdom
⨯
Alexandra Sampson,

Affiliation Comparative Biomedical Sciences, The Royal Veterinary College, London, United Kingdom
⨯
Hiroyuki Nakamura,

Affiliation Kennedy Institute of Rheumatology, Oxford, United Kingdom

http://orcid.org/0000-0002-2524-3063

⨯
Hideaki Nagase,

Affiliation Kennedy Institute of Rheumatology, Oxford, United Kingdom

http://orcid.org/0000-0002-8563-2263

⨯
Alessandra Carriero,

Affiliation Department of Biomedical Engineering, Florida Institute of Technology, Melbourne, FL, United States of America

http://orcid.org/0000-0001-8103-4795

⨯
Sandra Shefelbine,

Affiliation College of Engineering, Northeastern University, Boston, MA, United States of America
⨯
Andrew A. Pitsillides,

Affiliation Comparative Biomedical Sciences, The Royal Veterinary College, London, United Kingdom
⨯
George Bou-Gharios

* E-mail: ggharios@liverpool.ac.uk

Affiliation Department of Musculoskeletal Biology, Institute of Ageing and Chronic Disease, University of Liverpool, Apex building, Liverpool, United Kingdom
⨯

Overexpression of TIMP-3 in Chondrocytes Produces Transient Reduction in Growth Plate Length but Permanently Reduces Adult Bone Quality and Quantity

Blandine Poulet,
Ke Liu,
Darren Plumb,
Phoung Vo,
Mittal Shah,
Katherine Staines,
Alexandra Sampson,
Hiroyuki Nakamura,
Hideaki Nagase,
Alessandra Carriero

Published: December 21, 2016
https://doi.org/10.1371/journal.pone.0167971

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Osteoblasts
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Chondrocytes
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Bone development
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Cartilage
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Growth plate
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