Stability of Circulating Blood-Based MicroRNAs – Pre-Analytic Methodological Considerations

Charlotte Glinge; Sebastian Clauss; Kim Boddum; Reza Jabbari; Javad Jabbari; Bjarke Risgaard; Philipp Tomsits; Bianca Hildebrand; Stefan Kääb; Reza Wakili; Thomas Jespersen; Jacob Tfelt-Hansen

doi:10.1371/journal.pone.0167969

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Open Access

Peer-reviewed

Research Article

Stability of Circulating Blood-Based MicroRNAs – Pre-Analytic Methodological Considerations

Charlotte Glinge ,

Contributed equally to this work with: Charlotte Glinge, Sebastian Clauss

* E-mail: cglinge@gmail.com

Affiliation Department of Cardiology, the Heart Centre, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
⨯
Sebastian Clauss ,

Contributed equally to this work with: Charlotte Glinge, Sebastian Clauss

Affiliations Department of Medicine I, University Hospital Munich, Campus Grosshadern, Ludwig-Maximilians University Munich (LMU), Munich, Germany, Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, United States of America, DZHK (German Centre for Cardiovascular Research), Partner Site Munich, Munich Heart Alliance (MHA), Munich, Germany
⨯
Kim Boddum,

Affiliation Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark
⨯
Reza Jabbari,

Affiliation Department of Cardiology, the Heart Centre, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
⨯
Javad Jabbari,

Affiliation Department of Cardiology, the Heart Centre, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
⨯
Bjarke Risgaard,

Affiliation Department of Cardiology, the Heart Centre, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
⨯
Philipp Tomsits,

Affiliations Department of Medicine I, University Hospital Munich, Campus Grosshadern, Ludwig-Maximilians University Munich (LMU), Munich, Germany, DZHK (German Centre for Cardiovascular Research), Partner Site Munich, Munich Heart Alliance (MHA), Munich, Germany
⨯
Bianca Hildebrand,

Affiliation Department of Medicine I, University Hospital Munich, Campus Grosshadern, Ludwig-Maximilians University Munich (LMU), Munich, Germany
⨯
Stefan Kääb,

Affiliations Department of Medicine I, University Hospital Munich, Campus Grosshadern, Ludwig-Maximilians University Munich (LMU), Munich, Germany, DZHK (German Centre for Cardiovascular Research), Partner Site Munich, Munich Heart Alliance (MHA), Munich, Germany
⨯
Reza Wakili ,

¶‡ These authors also contributed equally to this work and share senior authorship on this work.

Affiliations Department of Medicine I, University Hospital Munich, Campus Grosshadern, Ludwig-Maximilians University Munich (LMU), Munich, Germany, DZHK (German Centre for Cardiovascular Research), Partner Site Munich, Munich Heart Alliance (MHA), Munich, Germany
⨯
Thomas Jespersen ,

¶‡ These authors also contributed equally to this work and share senior authorship on this work.

Affiliation Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark
⨯
Jacob Tfelt-Hansen

¶‡ These authors also contributed equally to this work and share senior authorship on this work.

Affiliation Department of Cardiology, the Heart Centre, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
⨯

Stability of Circulating Blood-Based MicroRNAs – Pre-Analytic Methodological Considerations

Charlotte Glinge,
Sebastian Clauss,
Kim Boddum,
Reza Jabbari,
Javad Jabbari,
Bjarke Risgaard,
Philipp Tomsits,
Bianca Hildebrand,
Stefan Kääb,
Reza Wakili

Published: February 2, 2017
https://doi.org/10.1371/journal.pone.0167969

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MicroRNAs
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Blood
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Blood plasma
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Specimen storage
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RNA isolation
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Analysis of variance
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