The Mitochondrial Permeability Transition Pore Regulator Cyclophilin D Exhibits Tissue-Specific Control of Metabolic Homeostasis

Rhianna C. Laker; Evan P. Taddeo; Yasir N. Akhtar; Mei Zhang; Kyle L. Hoehn; Zhen Yan

doi:10.1371/journal.pone.0167910

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Research Article

The Mitochondrial Permeability Transition Pore Regulator Cyclophilin D Exhibits Tissue-Specific Control of Metabolic Homeostasis

Rhianna C. Laker,

Affiliations Department of Medicine, University of Virginia School of Medicine, Charlottesville, VA, United States of America, Center for Skeletal Muscle Research at Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, VA, United States of America
⨯
Evan P. Taddeo,

Affiliation Department of Pharmacology, University of Virginia School of Medicine, Charlottesville, VA, United States of America
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Yasir N. Akhtar,

Affiliations Department of Medicine, University of Virginia School of Medicine, Charlottesville, VA, United States of America, Center for Skeletal Muscle Research at Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, VA, United States of America
⨯
Mei Zhang,

Affiliations Department of Medicine, University of Virginia School of Medicine, Charlottesville, VA, United States of America, Center for Skeletal Muscle Research at Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, VA, United States of America
⨯
Kyle L. Hoehn,

Affiliations Center for Skeletal Muscle Research at Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, VA, United States of America, Department of Pharmacology, University of Virginia School of Medicine, Charlottesville, VA, United States of America
⨯
Zhen Yan

* E-mail: zhen.yan@virginia.edu

Affiliations Department of Medicine, University of Virginia School of Medicine, Charlottesville, VA, United States of America, Center for Skeletal Muscle Research at Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, VA, United States of America, Department of Pharmacology, University of Virginia School of Medicine, Charlottesville, VA, United States of America, Department of Molecular Physiology & Biological Physics, University of Virginia School of Medicine, Charlottesville, VA, United States of America
⨯

The Mitochondrial Permeability Transition Pore Regulator Cyclophilin D Exhibits Tissue-Specific Control of Metabolic Homeostasis

Rhianna C. Laker,
Evan P. Taddeo,
Yasir N. Akhtar,
Mei Zhang,
Kyle L. Hoehn,
Zhen Yan

Published: December 22, 2016
https://doi.org/10.1371/journal.pone.0167910

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