Comparison of HapMap and 1000 Genomes Reference Panels in a Large-Scale Genome-Wide Association Study

• Paul S. de Vries,

  Affiliations Department of Epidemiology, Erasmus MC, Rotterdam, the Netherlands, University of Texas Health Science Center at Houston, Houston, TX, United States of America

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• Maria Sabater-Lleal,

  Affiliation Cardiovascular Medicine Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden

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• Daniel I. Chasman,

  Affiliations Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, United States of America, Harvard Medical School, Boston, MA, United States of America

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• Stella Trompet,

  Affiliations Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands, Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, the Netherlands

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• Tarunveer S. Ahluwalia,

  Affiliations Steno Diabetes Center Copenhagen, Gentofte, Denmark, Novo Nordisk Foundation Center For Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

  http://orcid.org/0000-0002-7464-3354

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• Alexander Teumer,

  Affiliation Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany

  http://orcid.org/0000-0002-8309-094X

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• Marcus E. Kleber,

  Affiliation Vth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany

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• Ming-Huei Chen,

  Affiliations Department of Neurology, Boston University School of Medicine, Boston, MA, United States of America, Framingham Heart Study, Population Sciences Branch, Division of Intramural Research National Heart Lung and Blood Institute, National Institutes of Health, Framingham, MA, United States of America

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• Jie Jin Wang,

  Affiliation Centre for Vision Research, Department of Ophthalmology, and Westmead Institute for Medical Research, University of Sydney, Sydney, Australia

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• John R. Attia,

  Affiliations Public Health Stream, Hunter Medical Research Institute, University of Newcastle, Newcastle, Australia, School of Medicine and Public Health, University of Newcastle, Newcastle, Australia

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• Riccardo E. Marioni,

  Affiliations Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, United Kingdom, Centre for Genomic and Experimental Medicine, University of Edinburgh, Edinburgh, United Kingdom, Queensland Brain Institute, University of Queensland, Brisbane, Australia

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• Maristella Steri,

  Affiliation Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, Monserrato, Cagliari, Italy

  http://orcid.org/0000-0001-5869-3872

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• Lu-Chen Weng,

  Affiliation Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN, United States of America

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• Rene Pool,

  Affiliations Department of Biological Psychology, Netherlands Twin Register, VU University, Amsterdam, the Netherlands, EMGO+ institute, VU University & VU medical center, Amsterdam, the Netherlands

  http://orcid.org/0000-0001-5579-0933

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• Vera Grossmann,

  Affiliation Center for Thrombosis and Hemostasis (CTH), University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany

  ⨯
• Jennifer A. Brody,

  Affiliation Department of Medicine, University of Washington, Seattle WA, United States of America

  ⨯
• Cristina Venturini,

  Affiliations Division of Infection and Immunology, UCL, London, United Kingdom, Department of Twin Research and Genetic Epidemiology, Kings College London, London, United Kingdom

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• Toshiko Tanaka,

  Affiliation Translational Gerontology Branch, National Institute on Aging, Baltimore, MD, United States of America

  ⨯
• Lynda M. Rose,

  Affiliation Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, United States of America

  ⨯
• Christopher Oldmeadow,

  Affiliations Public Health Stream, Hunter Medical Research Institute, University of Newcastle, Newcastle, Australia, School of Medicine and Public Health, University of Newcastle, Newcastle, Australia

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• Johanna Mazur,

  Affiliation Institute of Medical Biostatistics, Epidemiology and Informatics, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany

  ⨯
• Saonli Basu,

  Affiliation Division of Biostatistics, University of Minnesota, Minneapolis, MN, United States of America

  ⨯
• Mattias Frånberg,

  Affiliations Cardiovascular Medicine Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden, Department of Numerical Analysis and Computer Science, Stockholm University, Stockholm, Sweden

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• Qiong Yang,

  Affiliations Framingham Heart Study, Population Sciences Branch, Division of Intramural Research National Heart Lung and Blood Institute, National Institutes of Health, Framingham, MA, United States of America, Department of Biostatistics, Boston University School of Public Health, Boston, MA, United States of America

  ⨯
• Symen Ligthart,

  Affiliation Department of Epidemiology, Erasmus MC, Rotterdam, the Netherlands

  ⨯
• Jouke J. Hottenga,

  Affiliation Department of Biological Psychology, Netherlands Twin Register, VU University, Amsterdam, the Netherlands

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• Ann Rumley,

  Affiliation Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom

  ⨯
• Antonella Mulas,

  Affiliation Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, Monserrato, Cagliari, Italy

  ⨯
• Anton J. M. de Craen,

  Affiliation Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, the Netherlands

  ⨯
• Anne Grotevendt,

  Affiliation Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany

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• Kent D. Taylor,

  Affiliations Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute at Harbor/UCLA Medical Center, Torrance, CA, United States of America, Division of Genomic Outcomes, Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, CA, United States of America

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• Graciela E. Delgado,

  Affiliation Vth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany

  ⨯
• Annette Kifley,

  Affiliation Centre for Vision Research, Department of Ophthalmology, and Westmead Institute for Medical Research, University of Sydney, Sydney, Australia

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• Lorna M. Lopez,

  Affiliations Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, United Kingdom, Royal College of Surgeons in Ireland, Department of Psychiatry, Education and Research Centre, Beaumont Hospital, Dublin, Ireland, University College Dublin, UCD Conway Institute, Centre for Proteome Research, UCD, Belfield, Dublin, Ireland

  ⨯
• Tina L. Berentzen,

  Affiliation Institute of Preventive Medicine, Bispebjerg and Frederiksberg Hospital, The Capital Region, Copenhagen, Denmark

  ⨯
• Massimo Mangino,

  Affiliations Department of Twin Research and Genetic Epidemiology, Kings College London, London, United Kingdom, NIHR Biomedical Research Centre at Guy’s and St. Thomas’ Foundation Trust, London, United Kingdom

  ⨯
• Stefania Bandinelli,

  Affiliation Geriatric Unit, Azienda Sanitaria Firenze (ASF), Florence, Italy

  ⨯
• Alanna C. Morrison,

  Affiliation Department of Epidemiology, Erasmus MC, Rotterdam, the Netherlands

  ⨯
• Anders Hamsten,

  Affiliation Cardiovascular Medicine Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden

  ⨯
• Geoffrey Tofler,

  Affiliation Royal North Shore Hospital, Sydney University, Sydney, Australia

  ⨯
• Moniek P. M. de Maat,

  Affiliation Department of Hematology, Erasmus MC, Rotterdam, the Netherlands

  ⨯
• Harmen H. M. Draisma,

  Affiliations Department of Biological Psychology, Netherlands Twin Register, VU University, Amsterdam, the Netherlands, Neuroscience Campus Amsterdam, Amsterdam, the Netherlands

  ⨯
• Gordon D. Lowe,

  Affiliation Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom

  ⨯
• Magdalena Zoledziewska,

  Affiliation Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, Monserrato, Cagliari, Italy

  ⨯
• Naveed Sattar,

  Affiliation BHF Glasgow Cardiovascular Research Centre, Faculty of Medicine, Glasgow, United Kingdom

  ⨯
• Karl J. Lackner,

  Affiliation Institute of Clinical Chemistry and Laboratory Medicine, University Medical Center, Johannes Gutenberg University Mainz, Mainz, Germany

  ⨯
• Uwe Völker,

  Affiliation Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany

  ⨯
• Barbara McKnight,

  Affiliation Department of Biostatistics, University of Washington, Seattle, WA, United States of America

  ⨯
• Jie Huang,

  Affiliation Department of Human Genetics, Wellcome Trust Sanger Institute, Hinxton, Cambridge, United Kingdom

  ⨯
• Elizabeth G. Holliday,

  Affiliation Public Health Stream, Hunter Medical Research Institute, and School of Medicine and Public Health, University of Newcastle, Newcastle, Australia

  ⨯
• Mark A. McEvoy,

  Affiliation School of Medicine and Public Health, University of Newcastle, Newcastle, Australia

  ⨯
• John M. Starr,

  Affiliations Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, United Kingdom, Alzheimer Scotland Dementia Research Centre, University of Edinburgh, Edinburgh, United Kingdom

  ⨯
• Pirro G. Hysi,

  Affiliation Department of Twin Research and Genetic Epidemiology, Kings College London, London, United Kingdom

  ⨯
• Dena G. Hernandez,

  Affiliation Laboratory of Neurogenetics, National Institute on Aging, Bethesda, MD, United States of America

  ⨯
• Weihua Guan,

  Affiliation Division of Biostatistics, University of Minnesota, Minneapolis, MN, United States of America

  ⨯
• Fernando Rivadeneira,

  Affiliations Department of Epidemiology, Erasmus MC, Rotterdam, the Netherlands, Department of Internal Medicine, Erasmus MC, Rotterdam, the Netherlands

  ⨯
• Wendy L. McArdle,

  Affiliation School of Social and Community Medicine, University of Bristol, Bristol, United Kingdom

  ⨯
• P. Eline Slagboom,

  Affiliation Department of Molecular Epidemiology, Leiden University Medical Center, Leiden, the Netherlands

  ⨯
• Tanja Zeller,

  Affiliations Department of General and Interventional Cardiology, University Heart Centre, University Medical Center Hamburg-Eppendorf, Hamburg, Germany, German Center for Cardiovascular Research (DZHK), Partner Site Hamburg, Lübeck, Kiel, Hamburg, Germany

  ⨯
• Bruce M. Psaty,

  Affiliations Department of Medicine, Epidemiology, and Health Services, University of Washington, Seattle WA, United States of America, Group Health Research Institute, Group Health Cooperative, Seattle WA, United States of America

  ⨯
• André G. Uitterlinden,

  Affiliations Department of Epidemiology, Erasmus MC, Rotterdam, the Netherlands, Department of Internal Medicine, Erasmus MC, Rotterdam, the Netherlands

  ⨯
• Eco J. C. de Geus,

  Affiliations Department of Biological Psychology, Netherlands Twin Register, VU University, Amsterdam, the Netherlands, EMGO+ institute, VU University & VU medical center, Amsterdam, the Netherlands

  ⨯
• David J. Stott,

  Affiliation Institute of Cardiovascular and Medical Sciences, Faculty of Medicine, University of Glasgow, Glasgow, United Kingdom

  ⨯
• Harald Binder,

  Affiliation Institute of Medical Biostatistics, Epidemiology and Informatics, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany

  ⨯
• Albert Hofman,

  Affiliations Department of Epidemiology, Erasmus MC, Rotterdam, the Netherlands, Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MS, United States of America

  ⨯
• Oscar H. Franco,

  Affiliation Department of Epidemiology, Erasmus MC, Rotterdam, the Netherlands

  ⨯
• Jerome I. Rotter,

  Affiliations Los Angeles BioMedical Research Institute at Harbor-UCLA Medical Center, Institute for Translational Genomics and Population Sciences, Torrance, CA, United States of America, Division of Genomic Outcomes, Departments of Pediatrics & Medicine, Harbor-UCLA Medical Center, Torrance, CA, United States of America

  ⨯
• Luigi Ferrucci,

  Affiliation Translational Gerontology Branch, National Institute on Aging, Baltimore, MD, United States of America

  ⨯
• Tim D. Spector,

  Affiliation Department of Twin Research and Genetic Epidemiology, Kings College London, London, United Kingdom

  ⨯
• Ian J. Deary,

  Affiliations Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, United Kingdom, Department of Psychology, University of Edinburgh, Edinburgh, United Kingdom

  ⨯
• Winfried März,

  Affiliations Vth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany, Synlab Academy, Synlab Holding Deutschland GmbH, Mannheim, Germany, Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria

  ⨯
• Andreas Greinacher,

  Affiliation Institute for Immunology and Transfusion Medicine, University Medicine Greifswald, Greifswald, Germany

  ⨯
• Philipp S. Wild,

  Affiliations Preventive Cardiology and Preventive Medicine, Center for Cardiology, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany, Center for Thrombosis and Hemostasis (CTH), University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany, German Center for Cardiovascular Research (DZHK), Partner Site RhineMain, Mainz, Germany

  ⨯
• Francesco Cucca,

  Affiliation Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, Monserrato, Cagliari, Italy

  ⨯
• Dorret I. Boomsma,

  Affiliation Department of Biological Psychology, Netherlands Twin Register, VU University, Amsterdam, the Netherlands

  ⨯
• Hugh Watkins,

  Affiliation Cardiovascular Medicine Dept/Radcliffe Dept of Medicine, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom

  ⨯
• Weihong Tang,

  Affiliation Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN, United States of America

  ⨯
• Paul M. Ridker,

  Affiliations Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, United States of America, Harvard Medical School, Boston, MA, United States of America

  ⨯
• Jan W. Jukema,

  Affiliations Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands, Durrer Center for Cardiogenetic Research, Amsterdam, the Netherlands, Interuniversity Cardiology Institute of the Netherlands, Utrecht, the Netherlands

  ⨯
• Rodney J. Scott,

  Affiliations Information based Medicine Program, Hunter Medical Research Institute, University of Newcastle, Newcastle, Australia, School of Biomedical Sciences and Pharmacy, University of Newcastle, Newcastle, Australia

  ⨯
• Paul Mitchell,

  Affiliation Centre for Vision Research, Department of Ophthalmology, and Westmead Institute for Medical Research, University of Sydney, Sydney, Australia

  ⨯
• Torben Hansen,

  Affiliation Novo Nordisk Foundation Centre for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

  ⨯
• Christopher J. O'Donnell,

  Affiliations Framingham Heart Study, Population Sciences Branch, Division of Intramural Research National Heart Lung and Blood Institute, National Institutes of Health, Framingham, MA, United States of America, Cardiology Division, Massachusetts General Hospital, Boston, MA, United States of America

  ⨯
• Nicholas L. Smith,

  Affiliations Group Health Research Institute, Group Health Cooperative, Seattle WA, United States of America, Department of Epidemiology, University of Washington, Seattle WA, United States of America, Seattle Epidemiologic Research and Information Center, Department of Veteran Affairs Office of Research and Development, Seattle, WA, United States of America

  ⨯
• David P. Strachan,

  Affiliation Population Health Research Institute, St George's, University of London, London, United Kingdom

  ⨯
•  [ ... ],
• Abbas Dehghan

  * E-mail: a.dehghan@imperial.ac.uk

  Affiliations Department of Epidemiology, Erasmus MC, Rotterdam, the Netherlands, Department of Epidemiology and Biostatistics, Imperial College London, London, United Kingdom

  http://orcid.org/0000-0001-6403-016X

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