Impact of Sonic Hedgehog Pathway Expression on Outcome in HPV Negative Head and Neck Carcinoma Patients after Surgery and Adjuvant Radiotherapy

Elisabeth Enzenhofer; Thomas Parzefall; Georg Haymerle; Sven Schneider; Lorenz Kadletz; Gregor Heiduschka; Johannes Pammer; Felicitas Oberndorfer; Fritz Wrba; Benjamin Loader; Matthäus Christoph Grasl; Christos Perisanidis; Boban M. Erovic

doi:10.1371/journal.pone.0167665

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Open Access

Peer-reviewed

Research Article

Impact of Sonic Hedgehog Pathway Expression on Outcome in HPV Negative Head and Neck Carcinoma Patients after Surgery and Adjuvant Radiotherapy

Elisabeth Enzenhofer,

Affiliation Department of Otorhinolaryngology, Head and Neck Surgery, Medical University of Vienna, Vienna, Austria
⨯
Thomas Parzefall,

Affiliation Department of Otorhinolaryngology, Head and Neck Surgery, Medical University of Vienna, Vienna, Austria
⨯
Georg Haymerle,

Affiliation Department of Otorhinolaryngology, Head and Neck Surgery, Medical University of Vienna, Vienna, Austria
⨯
Sven Schneider,

Affiliation Department of Otorhinolaryngology, Head and Neck Surgery, Medical University of Vienna, Vienna, Austria
⨯
Lorenz Kadletz,

Affiliation Department of Otorhinolaryngology, Head and Neck Surgery, Medical University of Vienna, Vienna, Austria
⨯
Gregor Heiduschka,

Affiliation Department of Otorhinolaryngology, Head and Neck Surgery, Medical University of Vienna, Vienna, Austria
⨯
Johannes Pammer,

Affiliation Department of Clinical Pathology, Medical University of Vienna, Vienna, Austria
⨯
Felicitas Oberndorfer,

Affiliation Department of Clinical Pathology, Medical University of Vienna, Vienna, Austria
⨯
Fritz Wrba,

Affiliation Department of Clinical Pathology, Medical University of Vienna, Vienna, Austria
⨯
Benjamin Loader,

Affiliation Department of Otorhinolaryngology, Head and Neck Surgery, Rudolfstiftung, Vienna, Austria
⨯
Matthäus Christoph Grasl,

Affiliation Department of Otorhinolaryngology, Head and Neck Surgery, Medical University of Vienna, Vienna, Austria
⨯
Christos Perisanidis,

Affiliation Department of Oral and Maxillofacial Surgery, Medical University of Vienna, Vienna, Austria
⨯
Boban M. Erovic

* E-mail: boban.erovic@meduniwien.ac.at

Affiliation Department of Otorhinolaryngology, Head and Neck Surgery, Medical University of Vienna, Vienna, Austria
⨯

Impact of Sonic Hedgehog Pathway Expression on Outcome in HPV Negative Head and Neck Carcinoma Patients after Surgery and Adjuvant Radiotherapy

Elisabeth Enzenhofer,
Thomas Parzefall,
Georg Haymerle,
Sven Schneider,
Lorenz Kadletz,
Gregor Heiduschka,
Johannes Pammer,
Felicitas Oberndorfer,
Fritz Wrba,
Benjamin Loader

Published: December 5, 2016
https://doi.org/10.1371/journal.pone.0167665

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Head and neck cancers
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Cancer treatment
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Head and neck squamous cell carcinoma
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Radiation therapy
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Hedgehog signaling
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Surgical and invasive medical procedures
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Neck
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Otolaryngological procedures
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