Genomic Landscape of Experimental Bladder Cancer in Rodents and Its Application to Human Bladder Cancer: Gene Amplification and Potential Overexpression of Cyp2a5/CYP2A6 Are Associated with the Invasive Phenotype

Kazuhiro Kanemoto; Katsuhiro Fukuta; Noriyasu Kawai; Keiichi Tozawa; Masako Ochiai; Koji Okamoto; Sumiko Ohnami; Hiromi Sakamoto; Teruhiko Yoshida; Yae Kanai; Masaru Katoh; Takahiro Yasui; Kenjiro Kohri; Tadao Kakizoe; Hitoshi Nakagama

doi:10.1371/journal.pone.0167374

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Open Access

Peer-reviewed

Research Article

Genomic Landscape of Experimental Bladder Cancer in Rodents and Its Application to Human Bladder Cancer: Gene Amplification and Potential Overexpression of Cyp2a5/CYP2A6 Are Associated with the Invasive Phenotype

Kazuhiro Kanemoto ,

* E-mail: k.kanemoto7@gmail.com (KKa); hnakagam@ncc.go.jp (HN)

Affiliations Division of Cancer Development System, National Cancer Center Research Institute, Tokyo, Japan, Department of Nephro-Urology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
⨯
Katsuhiro Fukuta,

Affiliation Department of Nephro-Urology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
⨯
Noriyasu Kawai,

Affiliation Department of Nephro-Urology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
⨯
Keiichi Tozawa,

Affiliation Department of Nephro-Urology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
⨯
Masako Ochiai,

Affiliation Division of Cancer Development System, National Cancer Center Research Institute, Tokyo, Japan
⨯
Koji Okamoto,

Affiliation Division of Cancer Differentiation, National Cancer Center Research Institute, Tokyo, Japan
⨯
Sumiko Ohnami,

Affiliation Division of Genetics, National Cancer Center Research Institute, Tokyo, Japan
⨯
Hiromi Sakamoto,

Affiliation Division of Genetics, National Cancer Center Research Institute, Tokyo, Japan
⨯
Teruhiko Yoshida,

Affiliation Division of Genetics, National Cancer Center Research Institute, Tokyo, Japan
⨯
Yae Kanai,

Affiliation Division of Molecular Pathology, National Cancer Center Research Institute, Tokyo, Japan
⨯
Masaru Katoh,

Affiliation Department of Omics Network, National Cancer Center Research Institute, Tokyo, Japan
⨯
Takahiro Yasui,

Affiliation Department of Nephro-Urology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
⨯
Kenjiro Kohri,

Affiliation Department of Nephro-Urology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
⨯
Tadao Kakizoe,

Affiliation National Cancer Center Research Institute, Tokyo, Japan
⨯
Hitoshi Nakagama

* E-mail: k.kanemoto7@gmail.com (KKa); hnakagam@ncc.go.jp (HN)

Affiliation Division of Cancer Development System, National Cancer Center Research Institute, Tokyo, Japan
⨯

Genomic Landscape of Experimental Bladder Cancer in Rodents and Its Application to Human Bladder Cancer: Gene Amplification and Potential Overexpression of Cyp2a5/CYP2A6 Are Associated with the Invasive Phenotype

Kazuhiro Kanemoto,
Katsuhiro Fukuta,
Noriyasu Kawai,
Keiichi Tozawa,
Masako Ochiai,
Koji Okamoto,
Sumiko Ohnami,
Hiromi Sakamoto,
Teruhiko Yoshida,
Yae Kanai

Published: November 30, 2016
https://doi.org/10.1371/journal.pone.0167374

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