Astrocyte Structural and Molecular Response to Elevated Intraocular Pressure Occurs Rapidly and Precedes Axonal Tubulin Rearrangement within the Optic Nerve Head in a Rat Model

Shandiz Tehrani; Lauren Davis; William O. Cepurna; Tiffany E. Choe; Diana C. Lozano; Ashley Monfared; Lauren Cooper; Joshua Cheng; Elaine C. Johnson; John C. Morrison

doi:10.1371/journal.pone.0167364

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Open Access

Peer-reviewed

Research Article

Astrocyte Structural and Molecular Response to Elevated Intraocular Pressure Occurs Rapidly and Precedes Axonal Tubulin Rearrangement within the Optic Nerve Head in a Rat Model

Shandiz Tehrani ,

* E-mail: tehrani@ohsu.edu

Affiliation Casey Eye Institute, Department of Ophthalmology, Oregon Health & Science University, Portland, Oregon, United States of America
⨯
Lauren Davis,

Affiliation Casey Eye Institute, Department of Ophthalmology, Oregon Health & Science University, Portland, Oregon, United States of America
⨯
William O. Cepurna,

Affiliation Casey Eye Institute, Department of Ophthalmology, Oregon Health & Science University, Portland, Oregon, United States of America
⨯
Tiffany E. Choe,

Affiliation Casey Eye Institute, Department of Ophthalmology, Oregon Health & Science University, Portland, Oregon, United States of America
⨯
Diana C. Lozano,

Affiliation Casey Eye Institute, Department of Ophthalmology, Oregon Health & Science University, Portland, Oregon, United States of America
⨯
Ashley Monfared,

Affiliation Casey Eye Institute, Department of Ophthalmology, Oregon Health & Science University, Portland, Oregon, United States of America
⨯
Lauren Cooper,

Affiliation Casey Eye Institute, Department of Ophthalmology, Oregon Health & Science University, Portland, Oregon, United States of America
⨯
Joshua Cheng,

Affiliation Casey Eye Institute, Department of Ophthalmology, Oregon Health & Science University, Portland, Oregon, United States of America
⨯
Elaine C. Johnson,

Affiliation Casey Eye Institute, Department of Ophthalmology, Oregon Health & Science University, Portland, Oregon, United States of America
⨯
John C. Morrison

Affiliation Casey Eye Institute, Department of Ophthalmology, Oregon Health & Science University, Portland, Oregon, United States of America
⨯

Astrocyte Structural and Molecular Response to Elevated Intraocular Pressure Occurs Rapidly and Precedes Axonal Tubulin Rearrangement within the Optic Nerve Head in a Rat Model

Shandiz Tehrani,
Lauren Davis,
William O. Cepurna,
Tiffany E. Choe,
Diana C. Lozano,
Ashley Monfared,
Lauren Cooper,
Joshua Cheng,
Elaine C. Johnson,
John C. Morrison

Published: November 28, 2016
https://doi.org/10.1371/journal.pone.0167364

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Axons
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Optic nerve
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Protein kinases
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