Mitochondrial-Targeted Decyl-Triphenylphosphonium Enhances 2-Deoxy-D-Glucose Mediated Oxidative Stress and Clonogenic Killing of Multiple Myeloma Cells

Jeanine Schibler; Ann M. Tomanek-Chalkley; Jessica L. Reedy; Fenghuang Zhan; Douglas R. Spitz; Michael K. Schultz; Apollina Goel

doi:10.1371/journal.pone.0167323

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Research Article

Mitochondrial-Targeted Decyl-Triphenylphosphonium Enhances 2-Deoxy-D-Glucose Mediated Oxidative Stress and Clonogenic Killing of Multiple Myeloma Cells

Jeanine Schibler,

Affiliation Interdisciplinary Graduate Program in Molecular and Cellular Biology, University of Iowa, Iowa City, IA, United States of America
⨯
Ann M. Tomanek-Chalkley,

Affiliation Free Radical and Radiation Biology Program, Department of Radiation Oncology, University of Iowa, Iowa City, IA, United States of America
⨯
Jessica L. Reedy,

Affiliation Free Radical and Radiation Biology Program, Department of Radiation Oncology, University of Iowa, Iowa City, IA, United States of America
⨯
Fenghuang Zhan,

Affiliations Interdisciplinary Graduate Program in Molecular and Cellular Biology, University of Iowa, Iowa City, IA, United States of America, Department of Internal Medicine, University of Iowa, Iowa City, IA, United States of America
⨯
Douglas R. Spitz,

Affiliation Free Radical and Radiation Biology Program, Department of Radiation Oncology, University of Iowa, Iowa City, IA, United States of America
⨯
Michael K. Schultz,

Affiliations Free Radical and Radiation Biology Program, Department of Radiation Oncology, University of Iowa, Iowa City, IA, United States of America, Department of Radiology, University of Iowa, Iowa City, IA, United States of America
⨯
Apollina Goel

* E-mail: apollina-goel@uiowa.edu

Affiliations Interdisciplinary Graduate Program in Molecular and Cellular Biology, University of Iowa, Iowa City, IA, United States of America, Free Radical and Radiation Biology Program, Department of Radiation Oncology, University of Iowa, Iowa City, IA, United States of America
⨯

Mitochondrial-Targeted Decyl-Triphenylphosphonium Enhances 2-Deoxy-D-Glucose Mediated Oxidative Stress and Clonogenic Killing of Multiple Myeloma Cells

Jeanine Schibler,
Ann M. Tomanek-Chalkley,
Jessica L. Reedy,
Fenghuang Zhan,
Douglas R. Spitz,
Michael K. Schultz,
Apollina Goel

Published: November 30, 2016
https://doi.org/10.1371/journal.pone.0167323

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Hypoxia
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Flow cytometry
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Cell metabolism
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Multiple myeloma
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Oxidation
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Gene expression
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