Coordinated Activation of VEGF/VEGFR-2 and PPARδ Pathways by a Multi-Component Chinese Medicine DHI Accelerated Recovery from Peripheral Arterial Disease in Type 2 Diabetic Mice

Shuang He; Tiechan Zhao; Hao Guo; Yanzhi Meng; Gangjian Qin; David A. Goukassian; Jihong Han; Xuimei Gao; Yan Zhu

doi:10.1371/journal.pone.0167305

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Open Access

Peer-reviewed

Research Article

Coordinated Activation of VEGF/VEGFR-2 and PPARδ Pathways by a Multi-Component Chinese Medicine DHI Accelerated Recovery from Peripheral Arterial Disease in Type 2 Diabetic Mice

Shuang He,

Affiliations Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China, Research and Development Center of TCM, Tianjin International Joint Academy of Biotechnology & Medicine, Tianjin, China
⨯
Tiechan Zhao,

Affiliations Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China, Research and Development Center of TCM, Tianjin International Joint Academy of Biotechnology & Medicine, Tianjin, China
⨯
Hao Guo,

Affiliations Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China, Research and Development Center of TCM, Tianjin International Joint Academy of Biotechnology & Medicine, Tianjin, China
⨯
Yanzhi Meng,

Affiliations Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China, Research and Development Center of TCM, Tianjin International Joint Academy of Biotechnology & Medicine, Tianjin, China
⨯
Gangjian Qin,

Affiliations Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China, Department of Medicine-Cardiology and Department of Molecular Pharmacology and Biological Chemistry, Northwestern University Feinberg School of Medicine, Chicago, United States of America
⨯
David A. Goukassian,

Affiliation Center of Biomedical Research, Tufts University School of Medicine, Boston, United States of America
⨯
Jihong Han,

Affiliation State Key Laboratory of Medicinal Chemical Biology, and Collaborative Innovation Center for Biotherapy, Nankai University, Tianjin, China
⨯
Xuimei Gao,

Affiliation Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China
⨯
Yan Zhu

* E-mail: yanzhu.harvard@iCloud.com

Affiliations Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China, Research and Development Center of TCM, Tianjin International Joint Academy of Biotechnology & Medicine, Tianjin, China, Molecular Cardiology Research Institute, Tufts Medical Center and Tufts University School of Medicine, Boston, United States of America
⨯

Coordinated Activation of VEGF/VEGFR-2 and PPARδ Pathways by a Multi-Component Chinese Medicine DHI Accelerated Recovery from Peripheral Arterial Disease in Type 2 Diabetic Mice

Shuang He,
Tiechan Zhao,
Hao Guo,
Yanzhi Meng,
Gangjian Qin,
David A. Goukassian,
Jihong Han,
Xuimei Gao,
Yan Zhu

Published: December 8, 2016
https://doi.org/10.1371/journal.pone.0167305

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