Effects of Combined Treatment with Ionizing Radiation and the PARP Inhibitor Olaparib in BRCA Mutant and Wild Type Patient-Derived Pancreatic Cancer Xenografts

• Ines Lohse ,

  Contributed equally to this work with: Ines Lohse, Ramya Kumareswaran

  Affiliation Ontario Cancer Institute and Campbell Family Cancer Research Institute, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada

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• Ramya Kumareswaran ,

  Contributed equally to this work with: Ines Lohse, Ramya Kumareswaran

  Affiliation Ontario Cancer Institute and Campbell Family Cancer Research Institute, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada

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• Pinjiang Cao,

  Affiliation Ontario Cancer Institute and Campbell Family Cancer Research Institute, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada

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• Bethany Pitcher,

  Affiliation Ontario Cancer Institute and Campbell Family Cancer Research Institute, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada

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• Steven Gallinger,

  Affiliations Mount Sinai Hospital, Joseph and Wolf Lebovic Health Complex, Toronto, Ontario, Canada, Translational Research Initiative in Pancreas Cancer, Ontario Institute for Cancer Research, Toronto, Ontario, Canada

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• Robert G. Bristow,

  Affiliation Ontario Cancer Institute and Campbell Family Cancer Research Institute, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada

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• David W. Hedley

  * E-mail: david.hedley@uhn.on.ca

  Affiliations Ontario Cancer Institute and Campbell Family Cancer Research Institute, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada, Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada, Department of Medical Oncology and Haematology, Princess Margaret Cancer Center, Toronto, Ontario, Canada

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