TGFbeta Induces Binucleation/Polyploidization in Hepatocytes through a Src-Dependent Cytokinesis Failure

• Marco De Santis Puzzonia ,

  Contributed equally to this work with: Marco De Santis Puzzonia, Angela Maria Cozzolino

  Affiliation Istituto Pasteur Italia-Fondazione Cenci Bolognetti, Department of Cellular Biotechnologies and Haematology, Sapienza University of Rome, Rome, Italy

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• Angela Maria Cozzolino ,

  Contributed equally to this work with: Marco De Santis Puzzonia, Angela Maria Cozzolino

  Affiliations Istituto Pasteur Italia-Fondazione Cenci Bolognetti, Department of Cellular Biotechnologies and Haematology, Sapienza University of Rome, Rome, Italy, L. Spallanzani National Institute for Infectious Diseases, IRCCS, Rome, Italy

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• Germana Grassi,

  Affiliation L. Spallanzani National Institute for Infectious Diseases, IRCCS, Rome, Italy

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• Francesca Bisceglia,

  Affiliation Istituto Pasteur Italia-Fondazione Cenci Bolognetti, Department of Cellular Biotechnologies and Haematology, Sapienza University of Rome, Rome, Italy

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• Raffaele Strippoli,

  Affiliation Istituto Pasteur Italia-Fondazione Cenci Bolognetti, Department of Cellular Biotechnologies and Haematology, Sapienza University of Rome, Rome, Italy

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• Giulia Guarguaglini,

  Affiliation Institute of Molecular Biology and Pathology, CNR National Research Council, c/o Department of Biology and Biotechnology, Sapienza University of Rome, Rome, Italy

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• Franca Citarella,

  Affiliation Istituto Pasteur Italia-Fondazione Cenci Bolognetti, Department of Cellular Biotechnologies and Haematology, Sapienza University of Rome, Rome, Italy

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• Benedetto Sacchetti,

  Affiliation Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy

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• Marco Tripodi,

  Affiliations Istituto Pasteur Italia-Fondazione Cenci Bolognetti, Department of Cellular Biotechnologies and Haematology, Sapienza University of Rome, Rome, Italy, L. Spallanzani National Institute for Infectious Diseases, IRCCS, Rome, Italy

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• Alessandra Marchetti ,

  * E-mail: amicone@bce.uniroma1.it (LA); marchetti@bce.uniroma1.it (AM)

  ¶‡ These authors are joint senior authors on this work.

  Affiliation Istituto Pasteur Italia-Fondazione Cenci Bolognetti, Department of Cellular Biotechnologies and Haematology, Sapienza University of Rome, Rome, Italy

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• Laura Amicone

  * E-mail: amicone@bce.uniroma1.it (LA); marchetti@bce.uniroma1.it (AM)

  ¶‡ These authors are joint senior authors on this work.

  Affiliation Istituto Pasteur Italia-Fondazione Cenci Bolognetti, Department of Cellular Biotechnologies and Haematology, Sapienza University of Rome, Rome, Italy

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