Picroside II Attenuates Airway Inflammation by Downregulating the Transcription Factor GATA3 and Th2-Related Cytokines in a Mouse Model of HDM-Induced Allergic Asthma

Jin Choi; Bo Kyong Choi; Jin seok Kim; Jae-Won Lee; Hyun Ah Park; Hyung Won Ryu; Su Ui Lee; Kwang Woo Hwang; Won-Kee Yun; Hyoung-Chin Kim; Kyung-Seop Ahn; Sei-Ryang Oh; Hyun-Jun Lee

doi:10.1371/journal.pone.0167098

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Open Access

Peer-reviewed

Research Article

Picroside II Attenuates Airway Inflammation by Downregulating the Transcription Factor GATA3 and Th2-Related Cytokines in a Mouse Model of HDM-Induced Allergic Asthma

Jin Choi ,

Contributed equally to this work with: Jin Choi, Bo Kyong Choi

Affiliation Natural Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Cheongju, Chungbuk, Republic of Korea
⨯
Bo Kyong Choi ,

Contributed equally to this work with: Jin Choi, Bo Kyong Choi

Affiliations Natural Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Cheongju, Chungbuk, Republic of Korea, College of Pharmacy, Chung-Ang University, Seoul, Republic of Korea
⨯
Jin seok Kim,

Affiliation Natural Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Cheongju, Chungbuk, Republic of Korea
⨯
Jae-Won Lee,

Affiliation Natural Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Cheongju, Chungbuk, Republic of Korea
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Hyun Ah Park,

Affiliation Natural Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Cheongju, Chungbuk, Republic of Korea
⨯
Hyung Won Ryu,

Affiliation Natural Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Cheongju, Chungbuk, Republic of Korea
⨯
Su Ui Lee,

Affiliation Natural Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Cheongju, Chungbuk, Republic of Korea
⨯
Kwang Woo Hwang,

Affiliation College of Pharmacy, Chung-Ang University, Seoul, Republic of Korea
⨯
Won-Kee Yun,

Affiliation Laboratory Animal Resource Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Cheongju, Chungbuk, Republic of Korea
⨯
Hyoung-Chin Kim,

Affiliation Laboratory Animal Resource Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Cheongju, Chungbuk, Republic of Korea
⨯
Kyung-Seop Ahn,

Affiliation Natural Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Cheongju, Chungbuk, Republic of Korea
⨯
Sei-Ryang Oh,

Affiliation Natural Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Cheongju, Chungbuk, Republic of Korea
⨯
Hyun-Jun Lee

* E-mail: hjlee7@kribb.re.kr

Affiliation Natural Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Cheongju, Chungbuk, Republic of Korea

http://orcid.org/0000-0003-1293-6159

⨯

Picroside II Attenuates Airway Inflammation by Downregulating the Transcription Factor GATA3 and Th2-Related Cytokines in a Mouse Model of HDM-Induced Allergic Asthma

Jin Choi,
Bo Kyong Choi,
Jin seok Kim,
Jae-Won Lee,
Hyun Ah Park,
Hyung Won Ryu,
Su Ui Lee,
Kwang Woo Hwang,
Won-Kee Yun,
Hyoung-Chin Kim

Published: November 21, 2016
https://doi.org/10.1371/journal.pone.0167098

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