A Comparative Study of SMN Protein and mRNA in Blood and Fibroblasts in Patients with Spinal Muscular Atrophy and Healthy Controls

Renske I. Wadman; Marloes Stam; Marc D. Jansen; Yana van der Weegen; Camiel A. Wijngaarde; Oliver Harschnitz; Peter Sodaar; Kees P. J. Braun; Dennis Dooijes; Henny H. Lemmink; Leonard H. van den Berg; W. Ludo van der Pol

doi:10.1371/journal.pone.0167087

Loading metrics

Open Access

Peer-reviewed

Research Article

A Comparative Study of SMN Protein and mRNA in Blood and Fibroblasts in Patients with Spinal Muscular Atrophy and Healthy Controls

Renske I. Wadman ,

* E-mail: R.I.Wadman@umcutrecht.nl (RIW); W.L.vanderPol@umcutrecht.nl (WLP)

Affiliation Brain Centre Rudolf Magnus, Department of Neurology and Neurosurgery, University Medical Centre Utrecht, Utrecht, The Netherlands
⨯
Marloes Stam,

Affiliation Brain Centre Rudolf Magnus, Department of Neurology and Neurosurgery, University Medical Centre Utrecht, Utrecht, The Netherlands
⨯
Marc D. Jansen,

Affiliation Brain Centre Rudolf Magnus, Department of Neurology and Neurosurgery, University Medical Centre Utrecht, Utrecht, The Netherlands
⨯
Yana van der Weegen,

Affiliation Brain Centre Rudolf Magnus, Department of Neurology and Neurosurgery, University Medical Centre Utrecht, Utrecht, The Netherlands
⨯
Camiel A. Wijngaarde,

Affiliation Brain Centre Rudolf Magnus, Department of Neurology and Neurosurgery, University Medical Centre Utrecht, Utrecht, The Netherlands
⨯
Oliver Harschnitz,

Affiliation Brain Centre Rudolf Magnus, Department of Neurology and Neurosurgery, University Medical Centre Utrecht, Utrecht, The Netherlands
⨯
Peter Sodaar,

Affiliation Brain Centre Rudolf Magnus, Department of Neurology and Neurosurgery, University Medical Centre Utrecht, Utrecht, The Netherlands
⨯
Kees P. J. Braun,

Affiliation Brain Centre Rudolf Magnus, Department of Neurology and Child Neurology, University Medical Centre Utrecht, Utrecht, The Netherlands
⨯
Dennis Dooijes,

Affiliation Department of Genetics, University Medical Centre Utrecht, Utrecht, The Netherlands
⨯
Henny H. Lemmink,

Affiliation Department of Genetics, University Medical Centre Groningen, Groningen, The Netherlands
⨯
Leonard H. van den Berg,

Affiliation Brain Centre Rudolf Magnus, Department of Neurology and Neurosurgery, University Medical Centre Utrecht, Utrecht, The Netherlands
⨯
W. Ludo van der Pol

* E-mail: R.I.Wadman@umcutrecht.nl (RIW); W.L.vanderPol@umcutrecht.nl (WLP)

Affiliation Brain Centre Rudolf Magnus, Department of Neurology and Neurosurgery, University Medical Centre Utrecht, Utrecht, The Netherlands
⨯

A Comparative Study of SMN Protein and mRNA in Blood and Fibroblasts in Patients with Spinal Muscular Atrophy and Healthy Controls

Renske I. Wadman,
Marloes Stam,
Marc D. Jansen,
Yana van der Weegen,
Camiel A. Wijngaarde,
Oliver Harschnitz,
Peter Sodaar,
Kees P. J. Braun,
Dennis Dooijes,
Henny H. Lemmink

Published: November 28, 2016
https://doi.org/10.1371/journal.pone.0167087

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Fibroblasts
Is the Subject Area "Fibroblasts" applicable to this article?

Thanks for your feedback.
Blood
Is the Subject Area "Blood" applicable to this article?

Thanks for your feedback.
Gene expression
Is the Subject Area "Gene expression" applicable to this article?

Thanks for your feedback.
Lysis (medicine)
Is the Subject Area "Lysis (medicine)" applicable to this article?

Thanks for your feedback.
Messenger RNA
Is the Subject Area "Messenger RNA" applicable to this article?

Thanks for your feedback.
Biomarkers
Is the Subject Area "Biomarkers" applicable to this article?

Thanks for your feedback.
Point mutation
Is the Subject Area "Point mutation" applicable to this article?

Thanks for your feedback.
Heterozygosity
Is the Subject Area "Heterozygosity" applicable to this article?

Thanks for your feedback.