Endoplasmic Reticulum-Targeted Subunit Toxins Provide a New Approach to Rescue Misfolded Mutant Proteins and Revert Cell Models of Genetic Diseases

• Humaira Adnan ,

  Contributed equally to this work with: Humaira Adnan, Zhenbo Zhang

  Affiliation Division of Molecular Structure and Function, The Hospital for Sick Children, Toronto, Ontario, Canada

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• Zhenbo Zhang ,

  Contributed equally to this work with: Humaira Adnan, Zhenbo Zhang

  Affiliation Division of Molecular Structure and Function, The Hospital for Sick Children, Toronto, Ontario, Canada

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• Hyun-Joo Park,

  Affiliation Division of Molecular Structure and Function, The Hospital for Sick Children, Toronto, Ontario, Canada

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• Chetankumar Tailor,

  Affiliation Division of Cell Biology, Research Institute, The Hospital for Sick Children, Toronto, Ontario, Canada

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• Clare Che,

  Affiliation Division of Molecular Structure and Function, The Hospital for Sick Children, Toronto, Ontario, Canada

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• Mustafa Kamani,

  Affiliation Division of Molecular Structure and Function, The Hospital for Sick Children, Toronto, Ontario, Canada

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• George Spitalny,

  Affiliation ERAD Therapeutics, Caledon, Ontario, Canada

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• Beth Binnington,

  Affiliation Division of Molecular Structure and Function, The Hospital for Sick Children, Toronto, Ontario, Canada

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• Clifford Lingwood

  * E-mail: cling@sickkids.on.ca

  Affiliations Division of Molecular Structure and Function, The Hospital for Sick Children, Toronto, Ontario, Canada, Department of Biochemistry, University of Toronto, Ontario, Canada, Department of Laboratory Medicine & Pathobiology, University of Toronto, Ontario, Canada

  http://orcid.org/0000-0001-9096-0061

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