A Nucleoside Anticancer Drug, 1-(3-C-Ethynyl-β-D-Ribo-Pentofuranosyl)Cytosine, Induces Depth-Dependent Enhancement of Tumor Cell Death in Spread-Out Bragg Peak (SOBP) of Proton Beam

• Kenichiro Maeda,

  Affiliation Department of Radiation Medicine, Graduate School of Medicine, Hokkaido University, Kita 15 Nishi 7, Kita-ku, Sapporo, Hokkaido, 060–8638, Japan

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• Hironobu Yasui,

  Affiliation Laboratory of Radiation Biology, Department of Environmental Veterinary Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Kita 18 Nishi 9, Kita-ku, Sapporo, Hokkaido, 060–0818, Japan

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• Tohru Yamamori,

  Affiliation Laboratory of Radiation Biology, Department of Environmental Veterinary Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Kita 18 Nishi 9, Kita-ku, Sapporo, Hokkaido, 060–0818, Japan

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• Taeko Matsuura,

  Affiliation Division of Quantum Science and Engineering, Faculty of Engineering, Hokkaido University, Kita 13 Nishi 8, Kita-ku, Sapporo, Hokkaido, 060–8628, Japan

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• Seishin Takao,

  Affiliation Proton Beam Therapy Center, Hokkaido University Hospital, Kita 14 Nishi 5, Kita-ku, Sapporo, Hokkaido, 060–8648, Japan

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• Motofumi Suzuki,

  Affiliation Laboratory of Radiation Biology, Department of Environmental Veterinary Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Kita 18 Nishi 9, Kita-ku, Sapporo, Hokkaido, 060–0818, Japan

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• Akira Matsuda,

  Affiliation Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita-12 Nishi-6, Kita-ku, Sapporo, Hokkaido, 060–0812, Japan

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• Osamu Inanami ,

  * E-mail: inanami@vetmed.hokudai.ac.jp (OI); shirato@med.hokudai.ac.jp (HS)

  Affiliation Laboratory of Radiation Biology, Department of Environmental Veterinary Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Kita 18 Nishi 9, Kita-ku, Sapporo, Hokkaido, 060–0818, Japan

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• Hiroki Shirato

  * E-mail: inanami@vetmed.hokudai.ac.jp (OI); shirato@med.hokudai.ac.jp (HS)

  Affiliations Department of Radiation Medicine, Graduate School of Medicine, Hokkaido University, Kita 15 Nishi 7, Kita-ku, Sapporo, Hokkaido, 060–8638, Japan, Global Institution for Collaborative Research and Education, Hokkaido University, Kita 14 Nishi 5, Sapporo, Hokkaido, 060–8648, Japan

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