Prediction of Impending Type 1 Diabetes through Automated Dual-Label Measurement of Proinsulin:C-Peptide Ratio

• Annelien Van Dalem ,

  Contributed equally to this work with: Annelien Van Dalem, Simke Demeester

  Affiliations Diabetes Research Center, Brussels Free University—VUB, Brussels, Belgium, Department of Clinical Chemistry and Radio-immunology, Universitair Ziekenhuis Brussel, Brussels, Belgium

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• Simke Demeester ,

  Contributed equally to this work with: Annelien Van Dalem, Simke Demeester

  Affiliations Diabetes Research Center, Brussels Free University—VUB, Brussels, Belgium, Department of Clinical Chemistry and Radio-immunology, Universitair Ziekenhuis Brussel, Brussels, Belgium

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• Eric V. Balti,

  Affiliation Diabetes Research Center, Brussels Free University—VUB, Brussels, Belgium

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• Bart Keymeulen,

  Affiliations Diabetes Research Center, Brussels Free University—VUB, Brussels, Belgium, Department of Diabetology, Universitair Ziekenhuis Brussel, Brussels, Belgium

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• Pieter Gillard,

  Affiliations Diabetes Research Center, Brussels Free University—VUB, Brussels, Belgium, Department of Endocrinology, Universitair Ziekenhuis Leuven, Belgium

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• Bruno Lapauw,

  Affiliation Department of Endocrinology, Universitair Ziekenhuis Gent, Ghent, Belgium

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• Christophe De Block,

  Affiliation Department of Endocrinology, Diabetology and Metabolism, Universitair Ziekenhuis Antwerpen, Edegem, Belgium

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• Pascale Abrams,

  Affiliation Department of Endocrinology and Diabetology, GZA Campus Sint Augustinus en Sint Vincentius, Wilrijk-Antwerp, Belgium

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• Eric Weber,

  Affiliation Department of Endocrinology and Diabetology, Clinique du Sud Luxembourg et Clinique Saint Joseph, Arlon, Belgium

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• Ilse Vermeulen,

  Affiliation Diabetes Research Center, Brussels Free University—VUB, Brussels, Belgium

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• Pieter De Pauw,

  Affiliation Diabetes Research Center, Brussels Free University—VUB, Brussels, Belgium

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• Daniël Pipeleers,

  Affiliation Diabetes Research Center, Brussels Free University—VUB, Brussels, Belgium

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• Ilse Weets ,

  * E-mail: ilse.weets@uzbrussel.be

  ¶‡ These authors also contributed equally to this work.

  Affiliations Diabetes Research Center, Brussels Free University—VUB, Brussels, Belgium, Department of Clinical Chemistry and Radio-immunology, Universitair Ziekenhuis Brussel, Brussels, Belgium

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• Frans K. Gorus ,

  ¶‡ These authors also contributed equally to this work.

  Affiliations Diabetes Research Center, Brussels Free University—VUB, Brussels, Belgium, Department of Clinical Chemistry and Radio-immunology, Universitair Ziekenhuis Brussel, Brussels, Belgium

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• Belgian Diabetes Registry

  ¶Membership of the Belgian Diabetes Registry is listed in the Acknowledgments.

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