Distinct Epigenetic Effects of Tobacco Smoking in Whole Blood and among Leukocyte Subtypes

Dan Su; Xuting Wang; Michelle R. Campbell; Devin K. Porter; Gary S. Pittman; Brian D. Bennett; Ma Wan; Neal A. Englert; Christopher L. Crowl; Ryan N. Gimple; Kelly N. Adamski; Zhiqing Huang; Susan K. Murphy; Douglas A. Bell

doi:10.1371/journal.pone.0166486

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Open Access

Peer-reviewed

Research Article

Distinct Epigenetic Effects of Tobacco Smoking in Whole Blood and among Leukocyte Subtypes

Dan Su ,

Contributed equally to this work with: Dan Su, Xuting Wang

Affiliation Environmental Genomics Group, Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, 27709, United States of America
⨯
Xuting Wang ,

Contributed equally to this work with: Dan Su, Xuting Wang

Affiliation Environmental Genomics Group, Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, 27709, United States of America

http://orcid.org/0000-0001-6781-8008

⨯
Michelle R. Campbell,

Affiliation Environmental Genomics Group, Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, 27709, United States of America

http://orcid.org/0000-0001-5415-6420

⨯
Devin K. Porter,

Affiliation Environmental Genomics Group, Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, 27709, United States of America
⨯
Gary S. Pittman,

Affiliation Environmental Genomics Group, Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, 27709, United States of America
⨯
Brian D. Bennett,

Affiliation Integrated Bioinformatics, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, 27709, United States of America
⨯
Ma Wan,

Affiliation Environmental Genomics Group, Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, 27709, United States of America
⨯
Neal A. Englert,

Affiliation Environmental Genomics Group, Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, 27709, United States of America

http://orcid.org/0000-0003-4193-4398

⨯
Christopher L. Crowl,

Affiliation Environmental Genomics Group, Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, 27709, United States of America
⨯
Ryan N. Gimple,

Affiliation Environmental Genomics Group, Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, 27709, United States of America

http://orcid.org/0000-0002-7189-3243

⨯
Kelly N. Adamski,

Affiliation Environmental Genomics Group, Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, 27709, United States of America
⨯
Zhiqing Huang,

Affiliation Duke University School of Medicine, Durham, NC, 27708, United States of America
⨯
Susan K. Murphy,

Affiliation Duke University School of Medicine, Durham, NC, 27708, United States of America
⨯
Douglas A. Bell

* E-mail: BELL1@niehs.nih.gov

Affiliation Environmental Genomics Group, Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, 27709, United States of America
⨯

Distinct Epigenetic Effects of Tobacco Smoking in Whole Blood and among Leukocyte Subtypes

Dan Su,
Xuting Wang,
Michelle R. Campbell,
Devin K. Porter,
Gary S. Pittman,
Brian D. Bennett,
Ma Wan,
Neal A. Englert,
Christopher L. Crowl,
Ryan N. Gimple

Published: December 9, 2016
https://doi.org/10.1371/journal.pone.0166486

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