Melatonin Receptor Agonists as the “Perioceutics” Agents for Periodontal Disease through Modulation of Porphyromonas gingivalis Virulence and Inflammatory Response

Wei Zhou; Xuan Zhang; Cai-Lian Zhu; Zhi-Yan He; Jing-Ping Liang; Zhong-Chen Song

doi:10.1371/journal.pone.0166442

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Peer-reviewed

Research Article

Melatonin Receptor Agonists as the “Perioceutics” Agents for Periodontal Disease through Modulation of Porphyromonas gingivalis Virulence and Inflammatory Response

Wei Zhou ,

Contributed equally to this work with: Wei Zhou, Xuan Zhang

Affiliations Department of Periodontology, Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Stomatology, 639 Zhi Zao Ju Road, Shanghai 200011, China, Shanghai Research Institute of Stomatology, Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Stomatology, 639 Zhi Zao Ju Road, Shanghai 200011, China
⨯
Xuan Zhang ,

Contributed equally to this work with: Wei Zhou, Xuan Zhang

Affiliation Department of Pharmacy, Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, 639 Zhi Zao Ju Road, Shanghai 200011, China
⨯
Cai-Lian Zhu,

Affiliation Shanghai Research Institute of Stomatology, Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Stomatology, 639 Zhi Zao Ju Road, Shanghai 200011, China
⨯
Zhi-Yan He,

Affiliation Shanghai Research Institute of Stomatology, Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Stomatology, 639 Zhi Zao Ju Road, Shanghai 200011, China
⨯
Jing-Ping Liang ,

* E-mail: szhongchen@sina.com (ZCS); liangjpdentist@126.com (JPL)

Affiliation Shanghai Research Institute of Stomatology, Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Stomatology, 639 Zhi Zao Ju Road, Shanghai 200011, China
⨯
Zhong-Chen Song

* E-mail: szhongchen@sina.com (ZCS); liangjpdentist@126.com (JPL)

Affiliation Department of Periodontology, Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Stomatology, 639 Zhi Zao Ju Road, Shanghai 200011, China
⨯

Melatonin Receptor Agonists as the “Perioceutics” Agents for Periodontal Disease through Modulation of Porphyromonas gingivalis Virulence and Inflammatory Response

Wei Zhou,
Xuan Zhang,
Cai-Lian Zhu,
Zhi-Yan He,
Jing-Ping Liang,
Zhong-Chen Song

Published: November 10, 2016
https://doi.org/10.1371/journal.pone.0166442

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Melatonin
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Bacterial biofilms
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Periodontal diseases
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Virulence factors
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Red blood cells
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Receptor antagonist therapy
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