Auranofin Inhibits Retinal Pigment Epithelium Cell Survival through Reactive Oxygen Species-Dependent Epidermal Growth Factor Receptor/ Mitogen-Activated Protein Kinase Signaling Pathway

Xiaodong Chen; Radouil Tzekov; Mingyang Su; Haiyan Hong; Wang Min; Aidong Han; Wensheng Li

doi:10.1371/journal.pone.0166386

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Research Article

Auranofin Inhibits Retinal Pigment Epithelium Cell Survival through Reactive Oxygen Species-Dependent Epidermal Growth Factor Receptor/ Mitogen-Activated Protein Kinase Signaling Pathway

Xiaodong Chen ,

Contributed equally to this work with: Xiaodong Chen, Radouil Tzekov

Affiliations Xiamen Eye Center of Xiamen University, Xiamen University, Xiamen, Fujian, China, Department of Ophthalmology, First Hospital of Xi'an, Shanxi Institute of Ophthalmology, Shanxi Provincial Key Laboratory of Ophthalmology, Xi'an, Shanxi, China, State Key Laboratory for Cellular Stress Biology, School of Life Sciences, Xiamen University, Xiangan, Xiamen, China
⨯
Radouil Tzekov ,

Contributed equally to this work with: Xiaodong Chen, Radouil Tzekov

Affiliations Department of Ophthalmology, University of South Florida, Tampa, Florida, United States of America, The Roskamp Institute, Sarasota, Florida, United States of America
⨯
Mingyang Su,

Affiliation State Key Laboratory for Cellular Stress Biology, School of Life Sciences, Xiamen University, Xiangan, Xiamen, China
⨯
Haiyan Hong,

Affiliation State Key Laboratory for Cellular Stress Biology, School of Life Sciences, Xiamen University, Xiangan, Xiamen, China
⨯
Wang Min,

Affiliation Interdepartmental Program in Vascular Biology and Therapeutics, Department of Pathology, Yale University School of Medicine, New Haven, Connecticut, United States of America
⨯
Aidong Han ,

* E-mail: drlws@qq.com (WL); ahan@xmu.edu.cn (AH)

Affiliation State Key Laboratory for Cellular Stress Biology, School of Life Sciences, Xiamen University, Xiangan, Xiamen, China
⨯
Wensheng Li

* E-mail: drlws@qq.com (WL); ahan@xmu.edu.cn (AH)

Affiliation Xiamen Eye Center of Xiamen University, Xiamen University, Xiamen, Fujian, China
⨯

Auranofin Inhibits Retinal Pigment Epithelium Cell Survival through Reactive Oxygen Species-Dependent Epidermal Growth Factor Receptor/ Mitogen-Activated Protein Kinase Signaling Pathway

Xiaodong Chen,
Radouil Tzekov,
Mingyang Su,
Haiyan Hong,
Wang Min,
Aidong Han,
Wensheng Li

Published: November 15, 2016
https://doi.org/10.1371/journal.pone.0166386

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