T Cell Production of IFNγ in Response to TLR7/IL-12 Stimulates Optimal B Cell Responses to Viruses

Kira Rubtsova; Anatoly V. Rubtsov; Kalani Halemano; Sam X. Li; John W. Kappler; Mario L. Santiago; Philippa Marrack

doi:10.1371/journal.pone.0166322

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Peer-reviewed

Research Article

T Cell Production of IFNγ in Response to TLR7/IL-12 Stimulates Optimal B Cell Responses to Viruses

Kira Rubtsova ,

* E-mail: rubtsovak@njhealth.org (KR); marrackp@njhealth.org (PM)

Affiliations Howard Hughes Medical Institute, Denver, Colorado, 80206, United States of America, Department of Biomedical Sciences, National Jewish Health and Department of Immunology and Microbiology, University of Colorado Health Sciences Center, Denver, Colorado 80206, United States of America
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Anatoly V. Rubtsov,

Affiliations Howard Hughes Medical Institute, Denver, Colorado, 80206, United States of America, Department of Biomedical Sciences, National Jewish Health and Department of Immunology and Microbiology, University of Colorado Health Sciences Center, Denver, Colorado 80206, United States of America
⨯
Kalani Halemano,

Affiliations Department of Medicine, University of Colorado Denver, Aurora, Colorado 80045, United States of America, Department of Immunology and Microbiology, University of Colorado Denver, Aurora, Colorado 80045, United States of America
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Sam X. Li,

Affiliations Department of Medicine, University of Colorado Denver, Aurora, Colorado 80045, United States of America, Department of Immunology and Microbiology, University of Colorado Denver, Aurora, Colorado 80045, United States of America
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John W. Kappler,

Affiliations Howard Hughes Medical Institute, Denver, Colorado, 80206, United States of America, Department of Biomedical Sciences, National Jewish Health and Department of Immunology and Microbiology, University of Colorado Health Sciences Center, Denver, Colorado 80206, United States of America, Department of Pharmacology, University of Colorado School of Medicine, Aurora, Colorado 80045, United States of America, Department of Biochemistry and Molecular Genetics, University of Colorado Health Sciences Center, Aurora, Colorado 80045, United States of America
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Mario L. Santiago,

Affiliations Department of Medicine, University of Colorado Denver, Aurora, Colorado 80045, United States of America, Department of Immunology and Microbiology, University of Colorado Denver, Aurora, Colorado 80045, United States of America
⨯
Philippa Marrack

* E-mail: rubtsovak@njhealth.org (KR); marrackp@njhealth.org (PM)

Affiliations Howard Hughes Medical Institute, Denver, Colorado, 80206, United States of America, Department of Biomedical Sciences, National Jewish Health and Department of Immunology and Microbiology, University of Colorado Health Sciences Center, Denver, Colorado 80206, United States of America, University of Colorado School of Medicine, Aurora, Colorado 80045, United States of America, Department of Biochemistry and Molecular Genetics, University of Colorado Health Sciences Center, Aurora, Colorado 80045, United States of America
⨯

T Cell Production of IFNγ in Response to TLR7/IL-12 Stimulates Optimal B Cell Responses to Viruses

Kira Rubtsova,
Anatoly V. Rubtsov,
Kalani Halemano,
Sam X. Li,
John W. Kappler,
Mario L. Santiago,
Philippa Marrack

Published: November 23, 2016
https://doi.org/10.1371/journal.pone.0166322

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