Regioselective Glucuronidation of Diosmetin and Chrysoeriol by the Interplay of Glucuronidation and Transport in UGT1A9-Overexpressing HeLa Cells

Xuejun Zeng; Jian Shi; Min Zhao; Qingwei Chen; Liping Wang; Huangyu Jiang; Feifei Luo; Lijun Zhu; Linlin Lu; Xinchun Wang; Zhongqiu Liu

doi:10.1371/journal.pone.0166239

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Open Access

Peer-reviewed

Research Article

Regioselective Glucuronidation of Diosmetin and Chrysoeriol by the Interplay of Glucuronidation and Transport in UGT1A9-Overexpressing HeLa Cells

Xuejun Zeng ,

Contributed equally to this work with: Xuejun Zeng, Jian Shi

Affiliations Department of Pharmacy, First Hospital Affiliated to Shihezi University, Shihezi, Xinjiang, 832002, China, International Institute for Translational Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, 510006, China
⨯
Jian Shi ,

Contributed equally to this work with: Xuejun Zeng, Jian Shi

Affiliation International Institute for Translational Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, 510006, China
⨯
Min Zhao,

Affiliation International Institute for Translational Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, 510006, China
⨯
Qingwei Chen,

Affiliations Department of Pharmacy, First Hospital Affiliated to Shihezi University, Shihezi, Xinjiang, 832002, China, International Institute for Translational Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, 510006, China
⨯
Liping Wang,

Affiliation International Institute for Translational Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, 510006, China
⨯
Huangyu Jiang,

Affiliation International Institute for Translational Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, 510006, China
⨯
Feifei Luo,

Affiliation International Institute for Translational Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, 510006, China
⨯
Lijun Zhu,

Affiliation International Institute for Translational Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, 510006, China
⨯
Linlin Lu,

Affiliation International Institute for Translational Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, 510006, China
⨯
Xinchun Wang ,

* E-mail: liuzq@gzucm.edu.cn (ZL); cwjwxc@163.com (XW)

Affiliation Department of Pharmacy, First Hospital Affiliated to Shihezi University, Shihezi, Xinjiang, 832002, China
⨯
Zhongqiu Liu

* E-mail: liuzq@gzucm.edu.cn (ZL); cwjwxc@163.com (XW)

Affiliation International Institute for Translational Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, 510006, China
⨯

Regioselective Glucuronidation of Diosmetin and Chrysoeriol by the Interplay of Glucuronidation and Transport in UGT1A9-Overexpressing HeLa Cells

Xuejun Zeng,
Jian Shi,
Min Zhao,
Qingwei Chen,
Liping Wang,
Huangyu Jiang,
Feifei Luo,
Lijun Zhu,
Linlin Lu,
Xinchun Wang

Published: November 10, 2016
https://doi.org/10.1371/journal.pone.0166239

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